K
Kuo-Chan Weng
Researcher at Washington University in St. Louis
Publications - 9
Citations - 307
Kuo-Chan Weng is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Mesoderm & Population. The author has an hindex of 4, co-authored 7 publications receiving 235 citations. Previous affiliations of Kuo-Chan Weng include The Texas Heart Institute & University of Houston.
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Journal ArticleDOI
Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors
Jose Francisco Islas,Yu Liu,Kuo-Chan Weng,Kuo-Chan Weng,Matthew J. Robertson,Shuxing Zhang,Allan Prejusa,John Harger,Dariya Tikhomirova,Dariya Tikhomirova,Mani Chopra,Dinakar Iyer,Mark Mercola,Robert G. Oshima,James T. Willerson,Vladimir N. Potaman,Robert J. Schwartz,Robert J. Schwartz +17 more
TL;DR: The data indicate that ETS2 and MESP1 play important roles in a genetic network that governs cardiopoiesis, as shown by the de novo appearance of core cardiac transcription factors, Ca2+ transients, and sarcomeres.
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Human Induced Pluripotent Stem-Cardiac-Endothelial-Tumor-on-a-Chip to Assess Anticancer Efficacy and Cardiotoxicity.
Kuo-Chan Weng,Yosuke K. Kurokawa,Brianna S. Hajek,Jack A. Paladin,Venktesh S. Shirure,Steven C. George +5 more
TL;DR: A three-dimensional microfluidic device that simultaneously cultures tumor cell spheroids with iPS-derived cardiomyocytes (iPS-CMs) and i PS-derived endothelial cells and could be used to enhance personalized drug testing safety and efficacy is developed.
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Reversible Photothermal Modulation of Electrical Activity of Excitable Cells using Polydopamine Nanoparticles.
Hamed Gholami Derami,Prashant Gupta,Kuo-Chan Weng,Anushree Seth,Rohit Gupta,Jonathan R. Silva,Baranidharan Raman,Srikanth Singamaneni +7 more
TL;DR: In this article, the reversible modulation of the electrical activity of neurons and cardiomyocytes is demonstrated using polydopamine (PDA) nanoparticles as photothermal nanotransducers.
Journal ArticleDOI
Genome-Wide Identification of MESP1 Targets Demonstrates Primary Regulation Over Mesendoderm Gene Activity
Benjamin Soibam,Benjamin Soibam,Ashley Benham,Jong Kim,Kuo-Chan Weng,Litao Yang,Xueping Xu,Matthew J. Robertson,Alon Azares,Austin J. Cooney,Robert J. Schwartz,Robert J. Schwartz,Yu Liu +12 more
TL;DR: The transcriptome of a pure population of differentiating MESP1‐marked cells found that they chiefly contribute to the mesendoderm lineage, supporting a novel pivotal role of it in regulating target gene epigenetics.
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cis-regulatory control of Mesp1 expression by YY1 and SP1 during mouse embryogenesis
TL;DR: YY1 and SP1 independently and cooperatively govern the Mesp1 expression during embryogenesis, and two putative YY1 binding sites in the proximal promoter region of Mesp 1 gene were identified and mutation of these sites significantly reduced YY2‐induced activation of the M esp1 promoter.