K
Kurt Bienz
Researcher at University of Basel
Publications - 65
Citations - 6008
Kurt Bienz is an academic researcher from University of Basel. The author has contributed to research in topics: RNA & Viral replication. The author has an hindex of 34, co-authored 65 publications receiving 5856 citations.
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Journal ArticleDOI
Expression of Hepatitis C Virus Proteins Induces Distinct Membrane Alterations Including a Candidate Viral Replication Complex
Denise Egger,Benno Wölk,Rainer Gosert,Rainer Gosert,Leonardo Bianchi,Hubert E. Blum,Darius Moradpour,Kurt Bienz +7 more
TL;DR: It is proposed that the membranous web forms the viral replication complex in HCV-infected cells.
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Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons
Rainer Gosert,Denise Egger,Volker Lohmann,Ralf Bartenschlager,Hubert E. Blum,Kurt Bienz,Darius Moradpour +6 more
TL;DR: Metabolic labeling with 5-bromouridine 5′-triphosphate in the presence of actinomycin D revealed that the membranous web is the site of viral RNA synthesis and therefore represents the replication complex of HCV.
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RNA Replication of Mouse Hepatitis Virus Takes Place at Double-Membrane Vesicles
Rainer Gosert,Amornrat Kanjanahaluethai,Amornrat Kanjanahaluethai,Denise Egger,Kurt Bienz,Susan C. Baker +5 more
TL;DR: The ultrastructural analysis revealed double-membrane vesicles (DMVs) in the cytoplasm of mouse hepatitis virus-infected cells, concluding that the DMVs carry the MHV RNA replication complex and are the site ofMHV RNA synthesis.
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Membrane Rearrangement and Vesicle Induction by Recombinant Poliovirus 2C and 2BC in Human Cells
TL;DR: Despite the membrane reorganization and vesicle formation induced by 2C and 2BC proteins, no enhanced synthesis of lipid was observed and this may indicate a novel property of 2C that induces a complex interaction with intracellular membranes.
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Association of polioviral proteins of the P2 genomic region with the viral replication complex and virus-induced membrane synthesis as visualized by electron microscopic immunocytochemistry and autoradiography.
TL;DR: Using high resolution electron microscopic autoradiography and immunocytochemistry with monoclonal antibodies against poliovirus proteins of the P2 genomic region, the location of these proteins in respect to the virus-induced vesicle formation and the viral RNA synthesis was followed during the viral replication cycle.