L
L-T Chen
Researcher at Kaohsiung Medical University
Publications - 3
Citations - 247
L-T Chen is an academic researcher from Kaohsiung Medical University. The author has contributed to research in topics: DNA methylation & Autophagy. The author has an hindex of 2, co-authored 3 publications receiving 197 citations. Previous affiliations of L-T Chen include National Health Research Institutes & Chang Gung University.
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Journal ArticleDOI
Phase III randomized study of second line ADI-PEG 20 plus best supportive care versus placebo plus best supportive care in patients with advanced hepatocellular carcinoma.
Ghassan K. Abou-Alfa,Ghassan K. Abou-Alfa,Shukui Qin,Baek-Yeol Ryoo,Sheng-Nan Lu,Sheng-Nan Lu,Chia Jui Yen,Yin-Hsun Feng,H. Y. Lim,Francesco Izzo,Massimo Colombo,Debashis Sarker,Luigi Bolondi,Gina M. Vaccaro,William P. Harris,Z. Chen,Richard A Hubner,Tim Meyer,Weijing Sun,James J. Harding,James J. Harding,Ellen Hollywood,Jennifer Ma,Peter Justin Wan,Michele Ly,John S. Bomalaski,Amanda Johnston,Chen-Chun Lin,Yee Chao,L-T Chen,L-T Chen,L-T Chen +31 more
TL;DR: ADI-PEG 20 monotherapy did not demonstrate an OS benefit in second line setting for HCC, but was well tolerated and Strategies to enhance prolonged arginine depletion and synergize the effect of ADI- PEG 20 are underway.
Journal ArticleDOI
Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis
Barbara Delage,Phuong Luong,Lenushka Maharaj,Ciaran O'Riain,Nelofer Syed,Tim Crook,Eleftheria Hatzimichael,Alexandra Papoudou-Bai,Tracey J. Mitchell,Sean Whittaker,Rino Cerio,John G. Gribben,Nicholas R. Lemoine,John S. Bomalaski,C-F Li,Simon P. Joel,Jude Fitzgibbon,L-T Chen,L-T Chen,Peter W. Szlosarek +19 more
TL;DR: It is confirmed that the demethylating agent 5-Aza-dC reactivated ASS1 expression and rescued lymphoma cell lines from ADI-PEG20 cytotoxicity and represents a novel biomarker for evaluating the efficacy of arginine deprivation in patients with lymphoma.
Journal ArticleDOI
P-124 Nivolumab plus ipilimumab as neoadjuvant therapy for potentially resectable hepatocellular carcinoma
Y. Su,Yih Jyh Lin,C-F. Hsiao,Da-Liang Ou,Su-Jung Chen,Yen-Wen Wu,Wen-Chung Lee,J. Lin,C.-H. Hsu,M. Ho,Li-Chun Lu,T. Wu,S. Lai,Ying-Jui Chao,T. Chou,C.-J. Yen,L-T Chen,Y.-S. Shan,A-L Cheng +18 more