L. Trevor Young

TL;DR: In this paper, a cDNA array was used to generate an expression profile of lamotrigine-regulated genes in primary cultured rat hippocampus cells, and the results indicated that chronic treatment with lamotropic drugs increased the expression of eight genes and decreased six genes, and one of the upregulated genes is GABA-A receptor β subunit.

TL;DR: Support is provided for detectable differences in candidate immune and neurotrophic markers in individuals at high risk of developing bipolar disorder and for detectable changes over the clinical stages of illness development.

TL;DR: It is found that repeated amphetamine stimulation significantly induced hyperactive behaviour, decreased activities of mitochondrial complexes I and III, and increased 4-HNE-protein adducts in rat frontal cortex, and that chronic lithium treatment inhibited both amphetamine-induced hyperactivity and 4-hNE- protein adduction, indicating that prevention of 4- HNE-VMAT2 adduction may contribute in part to the pharmacological action of lithium for the treatment of bipolar disorder.

TL;DR: In this article, the authors found decreased IGFBP-2 expression in bipolar disorder patients compared with controls; this was especially pronounced in subjects not treated with lithium, and they suggested a role for IGFBPs in the etiology and pharmacotherapy of mood disorders.

TL;DR: It is found that GAP-43 protein levels in the hippocampal hilar region were significantly lower in bipolar disorder and schizophrenia subjects than in control subjects, suggesting that impairment of neuroplasticity may occur in the hippocampus of bipolar Disorder and schizophrenia patients.