L
L. Trevor Young
Researcher at University of Toronto
Publications - 144
Citations - 16200
L. Trevor Young is an academic researcher from University of Toronto. The author has contributed to research in topics: Bipolar disorder & Lithium (medication). The author has an hindex of 62, co-authored 143 publications receiving 15122 citations. Previous affiliations of L. Trevor Young include University of British Columbia & Mental Health Research Institute.
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Acute and chronic restraint stress alter the incidence of social conflict in male rats
TL;DR: It is indicated that acute and chronic restraint stress alter the incidence of aggression, and the relevance of this model of chronic stress to studies of stress-responsive disorders characterized by aggressive behavior is emphasized.
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Reduced brain 5-HT and elevated NE turnover and metabolites in bipolar affective disorder
L. Trevor Young,Jerry J. Warsh,Stephen J. Kish,Kathleen Shannak,Oleh Hornykeiwicz,Oleh Hornykeiwicz +5 more
TL;DR: The data suggest that decreased 5-HT metabolite levels and turnover may be common to all mood disorders, and increased cortical NE turnover, however, may be a more important component in the pathophysiology of bipolar disorder.
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Brain structural signature of familial predisposition for bipolar disorder: Replicable evidence for involvement of the right inferior frontal gyrus
Tomas Hajek,Tomas Hajek,Jeffrey Cullis,Tomas Novak,Miloslav Kopecek,Ryan Blagdon,Lukas Propper,Pavla Stopkova,Anne Duffy,Cyril Höschl,Rudolf Uher,Tomáš Paus,Tomáš Paus,L. Trevor Young,Martin Alda,Martin Alda +15 more
TL;DR: Brain structural changes in BD may result from interplay between illness burden and compensatory processes, which may be enhanced by lithium treatment, which could aid in identification of subjects at risk for BD even before any behavioral manifestations.
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Risk and Resilience Markers in Bipolar Disorder: Brain Responses to Emotional Challenge in Bipolar Patients and Their Healthy Siblings
TL;DR: Common changes with emotional challenge were identified in bipolar patients and their healthy siblings, and the siblings' unique increases in the medial frontal cortex appear to identify a compensatory response in this at-risk group, suggesting a potential marker of bipolar risk.
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Decreased brain [3H]inositol 1,4,5-trisphosphate binding in Alzheimer's disease
TL;DR: Inositol 1,4,5-trisphosphate receptor binding sites were studied in autopsied brains from 10 subjects with dementia of the Alzheimer type and 10 age-matched controls, demonstrating abnormalities beyond the muscarinic receptor recognition site in DAT.