L
L. Trevor Young
Researcher at University of Toronto
Publications - 144
Citations - 16200
L. Trevor Young is an academic researcher from University of Toronto. The author has contributed to research in topics: Bipolar disorder & Lithium (medication). The author has an hindex of 62, co-authored 143 publications receiving 15122 citations. Previous affiliations of L. Trevor Young include University of British Columbia & Mental Health Research Institute.
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Journal ArticleDOI
Lithium reduces the effects of rotenone-induced complex I dysfunction on DNA methylation and hydroxymethylation in rat cortical primary neurons.
Gustavo Scola,Gustavo Scola,Gustavo Scola,Helena Kyunghee Kim,Helena Kyunghee Kim,L. Trevor Young,L. Trevor Young,Mirian Salvador,Ana Cristina Andreazza,Ana Cristina Andreazza +9 more
TL;DR: It is suggested that decreased mitochondrial complex I activity may increase DNA methylation and hydroxymethylation in rat primary cortical neurons and that lithium may prevent these effects.
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Bipolar Disorder as a Mitochondrial Disease.
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Abstinence from repeated amphetamine treatment induces depressive-like behaviors and oxidative damage in rat brain
Yi Che,Yong-Hua Cui,Hua Tan,Ana Cristina Andreazza,L. Trevor Young,Jun-Feng Wang,Jun-Feng Wang +6 more
TL;DR: It is suggested that amphetamine abstinence displays depressive-like behaviors in rats and induces oxidative damage to lipids and RNA in rat brain and the process of oxidative stress may play a role in pathophysiological changes during drug abstinence from repeated amphetamine stimulation.
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Alterations in phosphorylated cAMP response element-binding protein (pCREB) signaling: an endophenotype of lithium-responsive bipolar disorder?
Martin Alda,Li Shao,Jun-Feng Wang,Catalina Lopez de Lara,Iris Jaitovich-Groisman,Veronique Lebel,Xiujun Sun,Anne Duffy,Paul Grof,Guy A. Rouleau,Gustavo Turecki,L. Trevor Young +11 more
TL;DR: Abnormalities of signal transduction are considered among the susceptibility factors for bipolar disorder (BD) and changes in G‐protein‐mediated signaling and subsequent modification of gene expression via transcription factors such as cAMP response element‐binding protein (CREB).
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DNA redox modulations and global DNA methylation in bipolar disorder: Effects of sex, smoking and illness state.
Deniz Ceylan,Deniz Ceylan,Gustavo Scola,Gustavo Scola,Zeliha Tunca,Cameron Isaacs-Trepanier,Cameron Isaacs-Trepanier,Gunes Can,Ana Cristina Andreazza,Ana Cristina Andreazza,L. Trevor Young,L. Trevor Young,Ayşegül Özerdem +12 more
TL;DR: Investigating DNA redox modulation and global DNA methylation and demethylation levels in patients with BD during euthymia, mania or depression in comparison to non-psychiatric controls suggests that levels of 8-OHdG may be affected by sex, illness states and smoking in BD.