Laetitia Weinhard

TL;DR: It is shown that deficient synaptic pruning is associated with weak synaptic transmission, decreased functional brain connectivity, deficits in social interaction and increased repetitive-behavior phenotypes that have been previously associated with autism and other neurodevelopmental and neuropsychiatric disorders.

TL;DR: This study shows direct evidence of microglia-synapse interaction wheremicroglia do not necessarily ‘eat’ post- synapse structure but ‘nibble’ on pre-synaptic terminals, much akin to trogocytosis by lymphocytes.

TL;DR: Light sheet fluorescence microscopy is used to follow microglia-synapse interactions in developing organotypic hippocampal cultures and this work proposes a mechanism for the facilitatory role of micro glial cells in synaptic circuits remodeling and maturation.

TL;DR: Investigation of morphological and functional features of microglia across early postnatal development as well as morphological features of both pre‐ and postsynaptic neuronal compartments in the mouse hippocampus found a sex‐dependent shift inmicroglia volume and phagocytic capacity across the first four postnatal weeks.

TL;DR: It is established that neuron–microglia interactions profoundly influence the functional maturation of excitatory presynaptic function.