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Lajos Baláspiri

Researcher at University of Szeged

Publications -  74
Citations -  1131

Lajos Baláspiri is an academic researcher from University of Szeged. The author has contributed to research in topics: Vasopressin & Amino acid. The author has an hindex of 14, co-authored 74 publications receiving 1104 citations. Previous affiliations of Lajos Baláspiri include University of Toledo Medical Center & Hungarian Academy of Sciences.

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Deletion analogues of transportan

TL;DR: Several novel short transportan analogues with similar cellular translocation properties to the parent peptide, but with reduced undesired cellular activity are designed and characterized.
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Structural Changes in the Arginine Vasopressin Molecule that Enhance Antidiuretic Activity and Specificity1

TL;DR: Testing the hypothesis that the lipophilic character of the side chain on the amino acid in the 4-position plays a key role in endowing vasopressin analogs with enhanced antidiuretic specificity found that substitution of valine for glutamine did indeed enhance specificity.
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Interaction between synthetic amyloid-β-peptide (1–40) and its aggregation inhibitors studied by electrospray ionization mass spectrometry†

TL;DR: Electrospray ionization mass spectrometric studies proved that there is a hydrophobic interaction between amyloid-beta-peptide (1-40) and melatonin and the proteolytic investigations suggested that the interaction took place on the 29-40 amyloids- beta- peptide segment.
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Synthese von Diazoketonen aus Acylaminosäuren unter Verwendung von gemischten Anhydriden bzw. N, N′–Dicyclohexyl-carbodiimid†

TL;DR: Aus Benzyloxycarbonyl and t-Butyloxy carbonyl-aminosauren werden uber gemischte Anhydride oder mittels N, N′-Dicyclohexyl-carbodiimid durch Reaktion with Diazomethan Diazoketone hergestellt, wobei die in der Literatur [6] [7] erwahnte Oxazolonbildung nicht beobachtet wird.
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Synthesis and some pharmacological properties of deamino(4-threonine,8-D-arginine)vasopressin and deamino(8-D-arginine)vasopressin, highly potent and specific antidiuretic peptides, and (8-D-arginine)vasopressin and deamino-arginine-vasopressin.

TL;DR: Threonine subsitution has thus brought about a significant enhancement in antidiuretic specificity, a finding entirely consistent with earlier observations that enhancement of lipophilicity at position 4 alone or in combination in arginine-vasopressin can lead to enhanced antidiUREtic specificity.