M
Mattias Hällbrink
Researcher at Stockholm University
Publications - 67
Citations - 6580
Mattias Hällbrink is an academic researcher from Stockholm University. The author has contributed to research in topics: Cell-penetrating peptide & Peptide. The author has an hindex of 35, co-authored 67 publications receiving 6021 citations. Previous affiliations of Mattias Hällbrink include University Institute of Technology, Burdwan University & Karolinska University Hospital.
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PatentDOI
Cell Penetrating Peptides
Mattias Hällbrink,Margus Pooga,Madis Tallin Unive Metsis,Priit Kogerman,Andreas Valkna,Anne Meikas,Maria Lindgren,Astrid Gräslund,Göran Eriksson,Claes Göran Östensson,Metka V. Budihna,Matjaz Zorko,Anna Elmquist,Ursel Soomets,Pontus Lundberg,Peter Järver,Külliki Saar,Samir El-Andaloussi,Kalle Kilk,Ülo Langel +19 more
TL;DR: In this paper, a method for predicting or designing, detecting, and/or verifying a novel cell-penetrating peptide (CPP) was proposed and used for treating and preventing a medical condition.
Journal ArticleDOI
Cell penetration by transportan
TL;DR: The cell-penetrating ability of transportan is not restricted by cell type, but seems to be a general feature of this peptide.
Journal ArticleDOI
Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo.
Margus Pooga,Margus Pooga,Ursel Soomets,Ursel Soomets,Mattias Hällbrink,Andres Valkna,Andres Valkna,Külliki Saar,Khadijeh Rezaei,Ulrika Kahl,Jing-Xia Hao,Xiao-Jun Xu,Zsuzsanna Wiesenfeld-Hallin,Tomas Hökfelt,Tamas Bartfai,Tamas Bartfai,Ülo Langel +16 more
TL;DR: It is shown that a 21-mer PNA, complementary to the human galanin receptor type 1 mRNA, coupled to the cellular transporter peptides, transportan or pAntennapedia, is efficiently taken up into Bowes cells where they block the expression of Galanin receptors.
Journal ArticleDOI
Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties
Joel Z. Nordin,Yi Lee,Pieter Vader,Imre Mäger,Imre Mäger,Henrik J. Johansson,Wolf Heusermann,Oscar P. B. Wiklander,Mattias Hällbrink,Yiqi Seow,Jarred J. Bultema,Jonathan D. Gilthorpe,Tim Davies,Paul J. Fairchild,Susanne Gabrielsson,Nicole Meisner-Kober,Janne Lehtiö,C. I. Edvard Smith,Matthew J.A. Wood,Samir El Andaloussi,Samir El Andaloussi +20 more
TL;DR: A systematic comparison between two protocols for EV purification: ultrafiltration with subsequent liquid chromatography (UF-LC) and differential ultracentrifugation (UC) for EV recovery shows that UF-LC is scalable and adaptable for EV isolation from complex media types such as stem cell media, which is of huge significance for future clinical applications involving EVs.
Journal ArticleDOI
Cargo delivery kinetics of cell-penetrating peptides
Mattias Hällbrink,Anders Florén,Anders Florén,Anna Elmquist,Anna Elmquist,Margus Pooga,Tamas Bartfai,Ülo Langel,Ülo Langel +8 more
TL;DR: The influence of CPPs on cellular 2-[(3)H]deoxyglucose-6-phosphate leakage is characterized and the membrane-disturbing potential appears to be correlated with the hydrophobic moment of the peptides.