Lakshmi Changolkar

TL;DR: It is found that Aβ plaques created a unique environment that facilitated the rapid amplification of proteopathic AD-tau seeds into large tau aggregates, initially appearing as NP tau, which was followed by the formation and spread of NFTs and NTs, likely through secondary seeding events.

TL;DR: Intracerebral inoculation of t Tau fibrils from AD brains results in the induction and propagation of tau inclusions in WT mice.

TL;DR: A sporadic tauopathy model is developed to test the hypothesis that cell-to-cell transmission of different tau strains occurs in nontransgenic (non-Tg) mice, and to investigate whether there are strain-specific differences in the pattern of tau transmission.

TL;DR: The results indicate that an increase in liver macroH2A1 during the transition from newborn to young-adult status contributes to a decrease in the expression levels of these genes, and the function of macroH 2A1 histones is not restricted to gene silencing but also involves fine tuning the expression of specific genes.

TL;DR: A new transgenic mouse line is generated expressing 6 human tau isoforms with equal 3R and 4R ratios, recapitulate distinct human t Tau strains in mouse brains with similar isoform compositions and cell type specificities, and further show the strain transmission pattern is independent of its isoform composition.