L
Larissa M. Podust
Researcher at University of Montana
Publications - 93
Citations - 4751
Larissa M. Podust is an academic researcher from University of Montana. The author has contributed to research in topics: Active site & Trypanosoma cruzi. The author has an hindex of 41, co-authored 86 publications receiving 4258 citations. Previous affiliations of Larissa M. Podust include University of Zurich & University of California, San Francisco.
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Journal ArticleDOI
Sterol 14alpha-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family.
David C. Lamb,Kay Fowler,Tobias Kieser,Nigel J. Manning,Larissa M. Podust,Michael R. Waterman,Diane E. Kelly,Steven L. Kelly +7 more
TL;DR: The annotation of the genome sequence of Streptomyces coelicolor A3(2) revealed a cytochrome P450 resembling various sterol 14alpha-demethylases (CYP51), and it is proposed that it is a member of a new CYP51 subfamily.
Journal ArticleDOI
Binding Mode and Potency of N-Indolyloxopyridinyl-4-aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51
Debora F. Vieira,Jun Yong Choi,Claudia M. Calvet,Jair L. Siqueira-Neto,Jonathan B. Johnston,Danielle Kellar,Jiri Gut,Michael D. Cameron,James H. McKerrow,William R. Roush,Larissa M. Podust +10 more
TL;DR: The structure–activity relationships (SAR) of an N-arylpiperazine series of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors designed to probe the impact of substituents in the terminal N-phenyl ring on binding mode, selectivity and potency are reported.
Journal ArticleDOI
Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents
Francesco Saccoliti,Valentina Noemi Madia,Valeria Tudino,Alessandro De Leo,Luca Pescatori,Antonella Messore,Daniela De Vita,Luigi Scipione,Reto Brun,Marcel Kaiser,Pascal Mäser,Claudia M. Calvet,Claudia M. Calvet,Gareth K. Jennings,Larissa M. Podust,Giacomo Pepe,Roberto Cirilli,Cristina Faggi,Annalise Di Marco,Maria Rosaria Battista,Vincenzo Summa,Roberta Costi,Roberto Di Santo +22 more
TL;DR: A series of new imidazole-based compounds structurally related to an antiprotozoal agent with nanomolar activity which was identified recently are designed and synthesized and possess micromolar activities against Trypanosoma brucei rhodesiense and Leishmania donovani and Nanomolar potency against Plasmodium falciparum.
Journal ArticleDOI
Expanding the binding envelope of CYP51 inhibitors targeting Trypanosoma cruzi with 4-aminopyridyl-based sulfonamide derivatives.
TL;DR: That the binding site was modulated in response to an incoming inhibitor for the first time characterizes TcCYP51 as a flexible target rather than a rigid template.
Journal ArticleDOI
R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi.
Jun Yong Choi,Claudia M. Calvet,Debora F. Vieira,Shamila S. Gunatilleke,Michael D. Cameron,James H. McKerrow,Larissa M. Podust,William R. Roush +7 more
TL;DR: In vitro efficacy data presented here for (R)-2-(R)-8, together with preliminary in vitro pharmacokinetic data suggest that this new CYP51 inhibitor scaffold series has potential to deliver drug candidates for treatment of T. cruzi infections.