L
Larry V. McIntire
Researcher at Rice University
Publications - 190
Citations - 16483
Larry V. McIntire is an academic researcher from Rice University. The author has contributed to research in topics: Endothelial stem cell & Cell adhesion molecule. The author has an hindex of 62, co-authored 190 publications receiving 16088 citations. Previous affiliations of Larry V. McIntire include University of Washington & Baylor College of Medicine.
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Journal ArticleDOI
The stimulation of arachidonic acid metabolism in human platelets by hydrodynamic stresses.
TL;DR: For platelets activated by shear--though arachidonic acid metabolism was stimulated--only 12-HETE was formed and essentially no cyclooxygenase metabolites were detected, which indicates that physical forces may initiate a different pathway for eicosanoid metabolism than most commonly used chemical stimuli.
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Differential effects of cytochalasin B on platelet release, aggregation and contractility: evidence against a contractile mechanism for the release of platelet granular contents.
John P. Kirkpatrick,Larry V. McIntire,Joel L. Moake,Joel L. Moake,Philip L. Cimo,Philip L. Cimo +5 more
TL;DR: Concentrations of cytochalasin B which impair platelet contractility do not inhibit the release of platelet dense granule contents and it is concluded that neither the platelet release reaction nor platelet aggregation is dependent on Platelet contractile mechanisms.
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Integrin α4β1/VCAM-1 pathway mediates primary adhesion of RAW117 lymphoma cells to hepatic sinusoidal endothelial cells under flow
Minas N. B. Papadimitriou,David G. Menter,Konstantinos Konstantopoulos,Garth L. Nicolson,Larry V. McIntire +4 more
TL;DR: Observations suggest that an interaction of integrin α4β1 on RAW117 cells with liver endothelial VCAM-1 occurs during the early stages of the adhesion process and may be important in liver metastasis.
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Fluid shear stress as a regulator of gene expression in vascular cells: possible correlations with diabetic abnormalities
TL;DR: This paper presents what is currently known regarding the molecular mechanisms responsible for signal transduction and gene regulation in vascular cells exposed to shear stress and considers the importance of the hemodynamic environment of vascular cells to increasing the understanding of diabetes.
Journal Article
Neutrophil adhesion to 24-hour IL-1-stimulated endothelial cells under flow conditions.
TL;DR: The results suggest that after a 24-h stimulation, primary adhesion depends on a distinct selectin-like interaction in which a HUVEC receptor binds carbohydrates on neutrophil glycoproteins, including L-selectin.