Showing papers in "Diabetes Research and Clinical Practice in 1999"

TL;DR: Results suggest that, together with glutathione peroxidase and catalase, Prx enzymes likely play an important role in eliminating peroxides generated during metabolism as well as during stimulation of cell surface receptors.

TL;DR: Improvements in pulmonary and nutritional care over the last few decades have led to dramatic improvements in the mortality rate, and now many patients with CF live into their third, fourth or fifth decades.

TL;DR: In this paper, the presence of injection related anxiety and phobia may influence compliance, glycaemic control, and quality of life in patients with insulin-treated diabetes, and a significant correlation between IAS and GAS was seen (Kendall's taua 0.30, 95% CI 0.19-0.41, P < 0.001).

TL;DR: The potential for continuous glucose monitoring to provide the valuable information necessary to make therapy adjustments that can dramatically improve patients' glycemic control and reduce the risk of long-term complications is highlighted.

TL;DR: Data is analyzed from a 75-g oral glucose tolerance test performed on 1051 high-risk subjects without medical history of diabetes at Diabetes Screening Clinic, Ramathibodi Hospital, Thailand to compare 1997 ADA diagnostic criteria for diabetes mellitus and other categories of glucose intolerance/1998 WHO Consultation criteria versus 1985 WHO criteria.

TL;DR: Proposed mechanisms involved in oxidative stress associated with hyperglycemia are glucose autooxidation, the formation of advanced glycosylation end products, and metabolic stress resulting from hyperglycesmia.

TL;DR: In this paper, a prospective, 1-year, multicenter, double-blind, randomized, parallel-group study was designed to show that repaglinide was at least equivalent to glyburide in patients with type 2 diabetes.

TL;DR: Antioxidant treatment strategies prevent or reverse nerve conduction velocity (NCV) deficits in diabetic rats by corrects the blood flow deficit and promotes normal endoneurial oxygenation.

TL;DR: Sedentary work and occupation had a significant association with diabetes, suggesting that sedentary lifestyle may be an important determinant for the higher prevalence of diabetes in an urbanising population.

TL;DR: The prevalence of diabetes mellitus and impaired glucose tolerance in the adult population of Catalonia and their association with obesity, central obesity, hypertension and smoking habit is similar to that observed in other Mediterranean countries.

TL;DR: This is the first report that an increase in delta mtDNA4977 and 8-OHdG is proportional to the severity of diabetic complications, and these are useful markers to evaluate oxidative mtDNA damage in the diabetic patients.

TL;DR: The prevalence of diabetes mellitus (DM) and impaired glucose tolerance (IGT) and their relationship to age and obesity was estimated in a population-based survey in urban and rural areas in Baluchistan province, Pakistan.

TL;DR: Results indicate that vanadate administration to diabetic animals normalizes blood glucose and causes marked improvement of altered lipid metabolism during diabetes, and suggest the possible use of vanadates as insulin replacement in the therapy of diabetes when administered at pharmacological doses.

TL;DR: It is suggested that AGEs can contribute to the development of microvascular complications through cell death of HUVECs and functional changes of the blood vessels and procoagulant activity in cultured HUV ECs.

TL;DR: New data is presented and previous work on the effects of superoxide anions on endothelial vascular function, such as intracellular Ca2+ signal cascade, formation and bioactivity of nitric oxide are reviewed, and superoxideAnion production as a two faced phenomenon is discussed.

TL;DR: Animal and clinical studies have shown that high doses of vitamin E treatment can apparently reverse some of the changes in the retinal and renal vessels.

TL;DR: It is shown that a significant number of Northland NZ Maori develop type 2 diabetes at an earlier age than expected and have a high incidence of renal complications.

TL;DR: Surveys show that diabetologists advocating intensive insulin therapy usually recommend an IMI shorter than 30 min, and the majority of patients with Type 1 diabetes use an I MI of < 30 min in daily life.

TL;DR: The results suggest that adhesion molecules may contribute to the development of atherosclerosis in the diabetic state.

TL;DR: Microalbuminuria and non-proliferative retinopathy are independently associated, and are both associated with increased blood pressure levels in the study population, and may also be a sensitive marker of early diabetic Retinopathy in African diabetic patients.

TL;DR: Results suggest poor glycemic control is associated with the increase in urine glycine betaine, carnitine, acetyl-carnitine and RBP excretion in diabetic patients, but < 50% of the observed increase in glycine Betaine excretion has been accounted for by the variables measured, suggesting other unidentified processes may also be involved.

TL;DR: It is concluded that mortality trends in diabetes mellitus differ in developing regions as compared to developed regions reflecting poor healthcare in general and diabetic care in particular.

TL;DR: Results were consistent with the idea that preheparin LPL mass might be relating to the insulin sensitivity enhanced by troglitazone, as well as LDL particle size.

TL;DR: It is concluded that most cases of diabetes in Japanese begin with decreased insulin secretion, but a small group of diabetes patients may start with insulin resistance, especially obese subjects.

TL;DR: This study suggests that postprandial hyperglycemia, particularly 2-h post prandial PG concentrations, is associated with high HbA1c levels in type 2 diabetic patients whose fasting PG levels were within normal or near-normal levels.

TL;DR: It is demonstrated that higher doses of vitamin E may further deteriorate insulin action and fibrinolysis in obese Type 2 diabetic patients.

TL;DR: A comparison of sib pairs, matched for age, duration of diabetes and the level of metabolic control showed that there was strong familial clustering of diabetic kidney disease in south Indians with Type 2 diabetes, independent of the familial clustered of diabetes.

TL;DR: Investigation of the physical and psychological well-being of adults with Type 1 (insulin-dependent) diabetes showed that older individuals, those with complications, women, the less physically active and those on lower incomes, were more likely to experience a poorer quality of life.

TL;DR: Strong and detailed evidence is provided that d-alpha-tocopherol can prevent hyperglycemia induced DAG-PKC activation by enhancing DAG kinase activity, probably through an antioxidant effect.

TL;DR: The prevalence of gestational diabetes mellitus in this region of the country is high as compared to other parts of Africa and the possible role and contribution of exposure of the general population in this area to chronic malnutrition as a result of prolonged famine, drought and war warrants further study.