L
Lars Carlsson
Researcher at Uppsala University
Publications - 14
Citations - 1836
Lars Carlsson is an academic researcher from Uppsala University. The author has contributed to research in topics: Actin & Sick leave. The author has an hindex of 11, co-authored 14 publications receiving 1800 citations.
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Journal ArticleDOI
Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells.
TL;DR: It is proposed that reversible association of actin with profilin in the cell may provide a mechanism for storage of monomeric actin and controlled turnover of microfilaments.
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Selective assay of monomeric and filamentous actin in cell extracts, using inhibition of deoxyribonuclease I
TL;DR: A simple and selective assay for monomeric and filamentous actin is presented, based on the inhibition of DNAase I by actin, which is rapid enough to detect changes in the polymerization state of actin in vitro over time intervals as short as 3 min.
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Depolymerization of F-actin by deoxyribonuclease I.
TL;DR: Deoxyribonuclease I causes depolymerization of filamentous muscle actin to form a stable complex of 1 mole DNAase I:1 mole actin, and heavy meromyosin binds tightly to actin filaments and blocks completely the DNA enzyme I: actin filament interaction.
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Reorganization of actin in platelets stimulated by thrombin as measured by the DNase I inhibition assay
TL;DR: The effect of thrombin stimulation on actin organization in human platelets has been analyzed by using the DNase I inhibition assay, which is selective for unpolymerized and filamentous actin, providing biochemical evidence for the suggestion that stimulation leads to rapid polymerization of actin.
Journal ArticleDOI
On the dynamics of the microfilament system in HeLa cells
Ingrid Blikstad,Lars Carlsson +1 more
TL;DR: Results show that significant changes in the actin pools can be induced in nucleated cells, however, several treatments which alter the morphology and motility of cells are not accompanied by an alteration in the G-/F-actin ratio.