L
Lars Maegdefessel
Researcher at Technische Universität München
Publications - 185
Citations - 7230
Lars Maegdefessel is an academic researcher from Technische Universität München. The author has contributed to research in topics: Medicine & Inflammation. The author has an hindex of 41, co-authored 144 publications receiving 5098 citations. Previous affiliations of Lars Maegdefessel include Stanford University & Martin Luther University of Halle-Wittenberg.
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Journal ArticleDOI
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
Yoko Kojima,Jens-Peter Volkmer,Mckenna Kelly Marie,Mete Civelek,Aldons J. Lusis,Clint L. Miller,Daniel Direnzo,Vivek Nanda,Jianqin Ye,Andrew J. Connolly,Eric E. Schadt,Thomas Quertermous,Paola Betancur,Lars Maegdefessel,Ljubica Perisic Matic,Ulf Hedin,Irving L. Weissman,Nicholas J. Leeper +17 more
TL;DR: It is found that administration of CD47-blocking antibodies reverses this defect in efferocytosis, normalizes the clearance of diseased vascular tissue, and ameliorates atherosclerosis in multiple mouse models.
Journal ArticleDOI
MicroRNA-26a Is a Novel Regulator of Vascular Smooth Muscle Cell Function
Nicholas J. Leeper,Azad Raiesdana,Yoko Kojima,Hyung J. Chun,Junya Azuma,Lars Maegdefessel,Ramendra K. Kundu,Thomas Quertermous,Philip S. Tsao,Joshua M. Spin +9 more
TL;DR: MicroRNA‐26a represents an important new regulator of SMC biology and a potential therapeutic target in AAA disease, and alters TGF‐β pathway signaling.
Journal ArticleDOI
Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development
Lars Maegdefessel,Junya Azuma,Ryuji Toh,Denis R. Merk,Alicia Deng,Jocelyn T. Chin,Uwe Raaz,Anke M. Schoelmerich,Azad Raiesdana,Nicholas J. Leeper,Michael V. McConnell,Ronald L. Dalman,Joshua M. Spin,Philip S. Tsao +13 more
TL;DR: Investigating the role of miRs in 2 murine models of experimental AAA suggests that therapeutic manipulation of miR-29b and its target genes holds promise for limiting AAA disease progression and protecting from rupture.
Journal ArticleDOI
MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion
Lars Maegdefessel,Junya Azuma,Ryuji Toh,Alicia Deng,Denis R. Merk,Azad Raiesdana,Nicholas J. Leeper,Uwe Raaz,Anke M. Schoelmerich,Michael V. McConnell,Ronald L. Dalman,Joshua M. Spin,Philip S. Tsao +12 more
TL;DR: The role of miR-21 is identified as a key modulator of proliferation and apoptosis of vascular wall smooth muscle cells during development of AAA in two established murine models and may offer a new therapeutic pathway that could be targeted to treat AAA in patients.
Journal ArticleDOI
Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.
Carlos Silvestre-Roig,Quinte Braster,Kanin Wichapong,Ernest Y. Lee,Jean Marie Teulon,Nihel Berrebeh,Janine Winter,José M. Adrover,Giancarlo Santiago Santos,Alexander Froese,Patricia Lemnitzer,Almudena Ortega-Gomez,Raphael Chevre,Julian A. Marschner,Ariane Schumski,Carla Winter,Laura Perez-Olivares,Chang Pan,Nicole Paulin,Tom Schoufour,Helene Hartwig,Silvia González-Ramos,Frits Kamp,Remco T. A. Megens,Kerri A. Mowen,Matthias Gunzer,Lars Maegdefessel,Lars Maegdefessel,Tilman M. Hackeng,Esther Lutgens,Mat J.A.P. Daemen,Julia von Blume,Hans-Joachim Anders,Viacheslav O. Nikolaev,Jean-Luc Pellequer,Christian Weber,Christian Weber,Andrés Hidalgo,Andrés Hidalgo,Gerry A. F. Nicolaes,Gerard C. L. Wong,Oliver Soehnlein +41 more
TL;DR: This work demonstrates that extracellular histone H4-mediated membrane lysis of smooth muscle cells (SMCs) triggers arterial tissue damage and inflammation, and identifies a form of cell death found at the core of chronic vascular disease that is instigated by leukocytes and can be targeted therapeutically.