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Andrés Hidalgo
Researcher at Centro Nacional de Investigaciones Cardiovasculares
Publications - 128
Citations - 13882
Andrés Hidalgo is an academic researcher from Centro Nacional de Investigaciones Cardiovasculares. The author has contributed to research in topics: Bone marrow & Inflammation. The author has an hindex of 50, co-authored 123 publications receiving 10195 citations. Previous affiliations of Andrés Hidalgo include Maastricht University & Spanish National Research Council.
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Journal ArticleDOI
Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow
Yoshio Katayama,Yoshio Katayama,Michela Battista,Wei Ming Kao,Andrés Hidalgo,Anna Julie Peired,Steven A. Thomas,Paul S. Frenette +7 more
TL;DR: It is demonstrated that enforced HSPC egress from BM niches depends critically on the nervous system, and results indicate that the sympathetic nervous system regulates the attraction of stem cells to their niche.
Journal ArticleDOI
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
Andrew Chow,Daniel Lucas,Daniel Lucas,Andrés Hidalgo,Andrés Hidalgo,Simón Méndez-Ferrer,Simón Méndez-Ferrer,Daigo Hashimoto,Christoph Scheiermann,Christoph Scheiermann,Michela Battista,Marylene Leboeuf,Colette Prophete,Colette Prophete,Nico van Rooijen,Masato Tanaka,Miriam Merad,Paul S. Frenette,Paul S. Frenette +18 more
TL;DR: Results highlight two antagonistic, tightly balanced pathways that regulate maintenance of HSCs/progenitors in the niche during homeostasis, in which MΦ cross talk with the Nestin+ niche cell promotes retention, and in contrast, SNS signals enhance egress.
Journal ArticleDOI
Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts.
Jordi Ochando,Chiho Homma,Yu Yang,Andrés Hidalgo,Alexandre Garin,Frank Tacke,Veronique Angeli,Yansui Li,Peter Boros,Yaozhong Ding,Rolf Jessberger,Rolf Jessberger,Giorgio Trinchieri,Sergio A. Lira,Gwendalyn J. Randolph,Jonathan S. Bromberg +15 more
TL;DR: Plasmacytoid dendritic cells (pDCs) are identified as phagocytic antigen-presenting cells essential for tolerance to vascularized cardiac allografts and home to the lymph nodes in tolerogenic conditions, where they mediate alloantigen-specific Treg cell development andallograft tolerance.
Journal ArticleDOI
Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance
Maria Casanova-Acebes,Christophe Pitaval,Linnea A. Weiss,César Nombela-Arrieta,Raphael Chevre,Noelia A-Gonzalez,Yuya Kunisaki,Dachuan Zhang,Nico van Rooijen,Leslie E. Silberstein,Christian Weber,Takashi Nagasawa,Paul S. Frenette,Antonio Castrillo,Andrés Hidalgo +14 more
TL;DR: It is reported that the homeostatic clearance of neutrophils provides cues that modulate the physiology of the bone marrow and is essential for the rhythmic egress of hematopoietic progenitors into the circulation.
Journal ArticleDOI
Neutrophils scan for activated platelets to initiate inflammation
Vinatha Sreeramkumar,José M. Adrover,Iván Ballesteros,María Isabel Cuartero,Jan Rossaint,Izaskun Bilbao,Maria Nacher,Maria Nacher,Christophe Pitaval,Irena Radovanovic,Yoshinori Fukui,Rodger P. McEver,Marie Dominique Filippi,Ignacio Lizasoain,Jesús Ruiz-Cabello,Alexander Zarbock,María A. Moro,Andrés Hidalgo,Andrés Hidalgo +18 more
TL;DR: Results reveal that recruited neutrophils scan for activated platelets, and they suggest that the neutrophil’ bipolarity allows the integration of signals present at both the endothelium and the circulation before inflammation proceeds, which alleviated collateral inflammatory damage to tissues in several injury models in mice.