Lashitew Gedamu

TL;DR: Of the several transition metals examined, only zinc facilitated activation of the DNA binding activity of recombinant MTF-1, and it is suggested that transition metals, other than zinc, that activate MT gene expression may do so by mechanisms independent of an increase in the DNAbinding activity of M TF-1.

TL;DR: The major stress proteins are detectable in the products of an in vitro translation system programmed with RNA isolated from heat shock- or metal ion-treated cells and can be inhibited by pretreatment with actinomycin D, suggesting that their expression is regulated at the transcriptional level.

TL;DR: The molecular masses and MRE complex migration of the zinc-responsive factors the authors detect are consistent with mouse and human metal-responsive transcription factor (MTF) and expression of the MTF cDNAs increases co-transfected MT promoter activity in both mammalian and trout cell lines underlining the conservation of MRE binding factor function among diverse species.

TL;DR: Results indicate that parietal and visceral endoderm cells actively express the metallothionein gene and further suggest that expression may be initiated at the earlier stage of primitive endODerm.

TL;DR: Results suggest that cathepsin B plays an important role in Leishmania survival within the host macrophages by activating latent TGF-beta1.