Lau Blonden

TL;DR: A fragile X site-induced breakpoint cluster region that exhibits length variation in fragile X chromosomes is identified and localization of the brain-expressed FMR-1 gene to this EcoRI fragment suggests the involvement of this gene in the phenotypic expression of the fragile X syndrome.

TL;DR: In vivo evidence is provided that β-cateninE654 is characterised by reduced affinity for cadherins, increased signalling and strongly increased phosphorylation at serine 675 by protein kinase A (PKA), which increases tumour initiation by enhancing Wnt signalling.

TL;DR: A new endothelial specific gene named FYVE, RhoGEF, and PH domain–containing 5 (FGD5) is identified that plays a crucial role in vascular pruning by activation of endothelial cell–targeted apoptosis and was linked to rising p21CIP1 levels in aging mice.

TL;DR: The first evidence for the plaque-destabilizing role of Ets2 in atherosclerosis development is provided by induction of an intraplaque proinflammatory phenotype in endothelial cells.

TL;DR: The zebrafish has great potential as a complementary animal model to study the pathogenesis of the fragile X syndrome, especially during embryonic development and a strong Fmrp expression in neurons of the brain and only a very weak expression in the testis is demonstrated.