Laura Aronoff

TL;DR: It is demonstrated that at steady state, TIMD4+LYVE1+MHC-IIloCCR2− resident cardiac macrophages self-renew with negligible blood monocyte input and a hierarchy of monocyte contribution to functionally distinct macrophage subsets is revealed.

TL;DR: The existence of three murine macrophage subpopulations based on common life cycle properties and core gene signatures are defined and provide a common starting point to understand tissue macrophages heterogeneity.

TL;DR: The murine heart contains two major conventional dendritic cell subsets, CD103+ and CD11b+, which differentially relied on local proliferation and precursor recruitment to maintain their tissue residency, and a BATF3‐dependent cDC surveillance system that prevents the transition of subclinical viral myocarditis to overt heart failure.

TL;DR: In this paper, single-cell transcriptomics of fate-mapped self-renewing cardiac resident macrophages (RMs) revealed transcriptionally diverse cell states with a core repertoire of reparative gene programs, including high expression of insulin-like growth factor-1 (Igf1).

TL;DR: To expand the current knowledge of DICER1 syndrome and to propose criteria for genetic testing based on experience at a pediatric tertiary care center.