L
Laura B. Creemers
Researcher at Utrecht University
Publications - 162
Citations - 7738
Laura B. Creemers is an academic researcher from Utrecht University. The author has contributed to research in topics: Cartilage & Osteoarthritis. The author has an hindex of 48, co-authored 147 publications receiving 6692 citations. Previous affiliations of Laura B. Creemers include University Medical Center Utrecht & University of Michigan.
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Journal ArticleDOI
Inflammatory profiles in canine intervertebral disc degeneration
Nicole Willems,Anna R. Tellegen,Niklas Bergknut,Laura B. Creemers,Jeannette Wolfswinkel,Christian Freudigmann,Karin Benz,Guy C. M. Grinwis,Marianna A. Tryfonidou,Bjoern P. Meij +9 more
TL;DR: Levels of prostaglandin E2 (PGE2) and CCL2 levels in degenerated and herniated IVDs were significantly higher compared with non-degenerated and non-herniated IVDs and reactive changes in the AF increased with advancing degeneration stages.
Journal ArticleDOI
The species-specific regenerative effects of notochordal cell-conditioned medium on chondrocyte-like cells derived from degenerated human intervertebral discs
Frances C. Bach,de Sah Stefan Vries,Anita Krouwels,Laura B. Creemers,Keita Keita Ito,Björn P. Meij,Marianna A. Tryfonidou +6 more
TL;DR: Bioactive compound(s) are present in NCCM of different species that may reverse human IVD degeneration, supporting further research into strategies based on NC-technology employing canine or porcine models for their translation into humans.
Journal ArticleDOI
Articular damage caused by metal plugs in a rabbit model for treatment of localized cartilage defects.
Roel J.H. Custers,Wouter J.A. Dhert,M.H.P. van Rijen,Abraham J. Verbout,Laura B. Creemers,Daniel B.F. Saris +5 more
TL;DR: OxZr and CoCr implants showed good osseointegration when used as a localized cartilage defect treatment in the rabbit knee; however, opposite cartilage damage was observed in all cases, suggesting caution is warranted using small metal implants for the treatment of localizedcartilage in the human patient.
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Articular Cartilage Evaluation After TruFit Plug Implantation Analyzed by Delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC)
J.E.J. Bekkers,Lambertus W. Bartels,Koen L. Vincken,Wouter J.A. Dhert,Laura B. Creemers,Daniel B.F. Saris,Daniel B.F. Saris +6 more
TL;DR: In this paper, the authors evaluated the quality of intra-articular cartilage, using the dGEMRIC scanning technique, 1 year after TruFit implantation, and found that the implantation of a TruFit plug does not lead to damage at the opposing articular Cartilage.
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Micro-CT quantification of subchondral endplate changes in intervertebral disc degeneration
J.P.H.J. Rutges,O.P. Jagt van der,F. C. Oner,Abraham J. Verbout,René M. Castelein,J.A. Kummer,Harrie Weinans,Laura B. Creemers,Wouter J.A. Dhert +8 more
TL;DR: The increase in bone volume combined with the increase in TrTh in endplate VOIs strongly suggest that the subchondral endplate condenses to a more dense structure in degenerated IVDs, which may negatively influence the diffusion and nutrition of the IVD.