L
Laura B. Creemers
Researcher at Utrecht University
Publications - 162
Citations - 7738
Laura B. Creemers is an academic researcher from Utrecht University. The author has contributed to research in topics: Cartilage & Osteoarthritis. The author has an hindex of 48, co-authored 147 publications receiving 6692 citations. Previous affiliations of Laura B. Creemers include University Medical Center Utrecht & University of Michigan.
Papers
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Journal ArticleDOI
Prospective Evaluation of Local Sustained Release of Celecoxib in Dogs with Low Back Pain.
Tijn Wiersema,Anna R. Tellegen,Martijn Beukers,Marijn van Stralen,Erik Wouters,Mandy van de Vooren,Nina Woike,George Mihov,Jens Christoph Thies,Laura B. Creemers,Marianna A. Tryfonidou,Björn P. Meij +11 more
TL;DR: In this paper, the clinical efficacy of intradiscally injected celecoxib (CXB)-loaded polyesteramide microspheres (PEAMs) was studied in a randomized prospective double-blinded placebo controlled veterinary study.
Journal ArticleDOI
Response to: cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection - authors' reply
TL;DR: Observation that IL-1 and tumor necrosis factor-alpha levels were upregulated in ACS, in contrast to the levels found previously upon characterization of ACS, may be due to the use of healthy subjects in the latter case, whereas the ACS prepared from osteoarthritis patients, the intended target population, was characterized.
Journal ArticleDOI
Contrast enhanced computed tomography for real-time quantification of glycosaminoglycans in cartilage tissue engineered constructs
J. Garcia,Alessia Longoni,Debby Gawlitta,Antoine J.W.P. Rosenberg,Mark W. Grinstaff,Juha Töyräs,Juha Töyräs,Harrie Weinans,Harrie Weinans,Laura B. Creemers,Behdad Pouran,Behdad Pouran +11 more
TL;DR: This work harnesses the electrostatic interactions between the negatively-charged glycosaminoglycans (GAGs) and a positively-charged contrast agent for longitudinal and non-destructive quantification of GAGs, providing valuable insight on GAG development and distribution in cartilage engineered constructs.
Journal ArticleDOI
Involvement of V-ATPases in the Digestion of Soft Connective Tissue Collagen
TL;DR: In conclusion, acidification by V-ATPases may represent an important mechanism in extracellular and intracellular collagen degradation in soft connective tissue.
Book ChapterDOI
Pro- and Anti-inflammatory Cytokine Profiles in Osteoarthritis
TL;DR: Differential profiles compared to healthy joints were found in the knee and other OA joints, whereby also joint damage induces a specific change in secretory pattern, suggesting that other soluble factors may be more promising as possible targets.