L
Laura B. Creemers
Researcher at Utrecht University
Publications - 162
Citations - 7738
Laura B. Creemers is an academic researcher from Utrecht University. The author has contributed to research in topics: Cartilage & Osteoarthritis. The author has an hindex of 48, co-authored 147 publications receiving 6692 citations. Previous affiliations of Laura B. Creemers include University Medical Center Utrecht & University of Michigan.
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Journal ArticleDOI
Of Mice, Men and Elephants: The Relation between Articular Cartilage Thickness and Body Mass
Jos Malda,Jos Malda,Janny C. de Grauw,Kim E M Benders,Marja Kik,Chris H.A. van de Lest,Laura B. Creemers,Wouter J.A. Dhert,P. René van Weeren +8 more
TL;DR: In this article, osteochondral cores were harvested post-mortem from the central sites of both medial and lateral femoral condyles of 58 different mammalian species ranging from 25 g (mouse) to 4000 kg (African elephant).
Journal ArticleDOI
Growth factor interactions in bone regeneration
Diederik H.R. Kempen,Laura B. Creemers,Jacqueline Alblas,Lichun Lu,Abraham J. Verbout,Michael J. Yaszemski,Wouter J.A. Dhert +6 more
TL;DR: This review provides an overview of the growth factor and cytokine combinations tested in translational bone regeneration studies and shows that their interaction may result in an enhancement or inhibition of bone formation.
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Reliability, reproducibility and variability of the traditional Histologic/Histochemical Grading System vs the new OARSI Osteoarthritis Cartilage Histopathology Assessment System
Roel J.H. Custers,Laura B. Creemers,Abraham J. Verbout,M.H.P. van Rijen,Wouter J.A. Dhert,Daniel B.F. Saris +5 more
TL;DR: Although the HHGS has proven to be an excellent tool for histological scoring of cartilage quality, the OOCHAS is recommended as the premium choice while stressing the importance of further research investigating the correlation of the histological results to macroscopic and biochemical parameters.
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Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection
TL;DR: Although OPG levels were higher and TGF-β levels were clearly lower in ACS than in SF, intraarticular ACS injection in OA patients did not result in significant changes in these cytokine levels, which may explain the limited effects found previously in vivo.
Journal ArticleDOI
Transplantation of germ cells from glial cell line-derived neurotrophic factor-overexpressing mice to host testes depleted of endogenous spermatogenesis by fractionated irradiation
Laura B. Creemers,Xiaojuan Meng,K. den Ouden,A. M. M. Van Pelt,F. Izadyar,M. Santoro,Hannu Sariola,Dirk G. de Rooij +7 more
TL;DR: An efficient method for depleting the seminiferous epithelium of host mice without appreciable adverse effects is devised and in these host mice, GDNF-overexpressing cells reproduced the aberrant phenotype found in the donor transgenic mice.