L
Laura B. Creemers
Researcher at Utrecht University
Publications - 162
Citations - 7738
Laura B. Creemers is an academic researcher from Utrecht University. The author has contributed to research in topics: Cartilage & Osteoarthritis. The author has an hindex of 48, co-authored 147 publications receiving 6692 citations. Previous affiliations of Laura B. Creemers include University Medical Center Utrecht & University of Michigan.
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Journal ArticleDOI
Intradiscal application of a PCLA-PEG-PCLA hydrogel loaded with celecoxib for the treatment of back pain in canines: What's in it for humans?
Anna R. Tellegen,Nicole Willems,Martijn Beukers,Guy C. M. Grinwis,Saskia G M Plomp,Clemens Bos,Maarten van Dijk,Mike de Leeuw,Laura B. Creemers,Marianna A. Tryfonidou,Björn P. Meij +10 more
TL;DR: This study showed the safety and effectiveness of intradiscal injections in vivo with a thermoresponsive PCLA–PEG–PCLA hydrogel loaded with celecoxib, a COX‐2 inhibitor, in dogs with chronic low back pain.
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Controlled release of celecoxib inhibits inflammation, bone cysts and osteophyte formation in a preclinical model of osteoarthritis.
Anna R. Tellegen,Imke Rudnik-Jansen,Behdad Pouran,H.M. de Visser,Harrie Weinans,Rachel E. Thomas,Marja Kik,Guy C. M. Grinwis,Jens Christoph Thies,Nina Woike,George Mihov,Pieter J. Emans,Björn P. Meij,Laura B. Creemers,Marianna A. Tryfonidou +14 more
TL;DR: The results suggest the application of celecoxib-loaded microspheres holds promise as novel, safe and effective treatment for inflammation and pain in OA.
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Spermatogonial stem cell transplantation.
F. Izadyar,Laura B. Creemers,Federica M.F. van Dissel-Emiliani,Ans M.M. van Pelt,Dirk G. de Rooij +4 more
TL;DR: Possibility opened by this technique include: (a) New ways to study fundamental aspects of spermatogenesis; (b) Generation of transgenic large domestic animals; (c) Protection of (young) male cancer patients from infertility due to chemotherapy or radiotherapy.
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Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis
J. Garcia,Jeroen Stein,Yunpeng Cai,Frank M. Riemers,Ezequiel Wexselblatt,Jesper Wengel,Marianna A. Tryfonidou,Avner Yayon,Kenneth A. Howard,Laura B. Creemers +9 more
TL;DR: This work demonstrates the use applicability of a hydrogel as a platform for combined local delivery of chondrocytes and an ADAMTS-targeting gapmer for catabolic gene modulation in OA.
Journal ArticleDOI
Biomaterials for intervertebral disc regeneration: past performance and possible future strategies.
EM Schutgens,Marianna A. Tryfonidou,TH Smit,F. C. Oner,Anita Krouwels,Keita Ito,Laura B. Creemers +6 more
TL;DR: As biomaterial application until now appears to have been based on a mix of mere availability and intuition, a more rational design is proposed for future use of biomaterials for IVD regeneration and high-throughput screening is used to identify optimally effective materials.