L
Laura E. Wade
Researcher at Research Triangle Park
Publications - 3
Citations - 1606
Laura E. Wade is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Nuclear receptor & Pregnane X receptor. The author has an hindex of 2, co-authored 3 publications receiving 1534 citations.
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Journal ArticleDOI
An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway
Steven A. Kliewer,John T. Moore,Laura E. Wade,Jeff L. Staudinger,Michael A. Watson,Stacey A. Jones,David D. McKee,Beverly B. Oliver,Timothy M. Willson,Rolf Zetterström,Thomas Perlmann,Jürgen M. Lehmann +11 more
TL;DR: The results provide evidence for the existence of a novel steroid hormone signaling pathway with potential implications in the regulation of steroid hormone and sterol homeostasis and the expression of the CYP3A family of steroid hydroxylases and modulates sterol and bile acid biosynthesis in vivo.
Journal ArticleDOI
Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library
Peter Brown,Tracey Smith-Oliver,Paul S. Charifson,Nicholas C. O. Tomkinson,Adam M. Fivush,Daniel D. Sternbach,Laura E. Wade,Lisa A. Orband-Miller,Derek J. Parks,Steven G. Blanchard,Steven A. Kliewer,Jürgen M. Lehmann,Timothy M. Willson +12 more
TL;DR: The synthesis of biased chemical libraries is an efficient approach to the identification of lead molecules for members of sequence-related receptor families and is well suited to the discovery of small-molecule ligands for orphan receptors.
Unusual signaling pathway of steroid hormones: Dual action of progesterone
H. K. Lee,G. D. Prestwich,B. Mouillac,H. H. Zingg,Steven A. Kliewer,John T. Moore,Laura E. Wade,Jeff L. Staudinger,Michael A. Watson,Stacey A. Jones,D.D. McKee,Beverly B. Oliver,T. M. Wilson,Rolf Zetterström,Thomas Perlmann,Jürgen M. Lehmann +15 more