L
Laura L. Dugan
Researcher at University of California, San Diego
Publications - 73
Citations - 9755
Laura L. Dugan is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Superoxide & Neuroprotection. The author has an hindex of 47, co-authored 72 publications receiving 9229 citations. Previous affiliations of Laura L. Dugan include Vanderbilt University Medical Center & Washington University in St. Louis.
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Journal ArticleDOI
Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate
Laura L. Dugan,Stefano L. Sensi,Lorella M.T. Canzoniero,Shawn D. Handran,Steven M. Rothman,T. S. Lin,Mark P. Goldberg,Dennis W. Choi +7 more
TL;DR: Data support the possibility that NMDA receptor-mediated, Ca(2+)-dependent uncoupling of neuronal mitochondrial electron transport may contribute to the oxidative stress initiated by glutamate exposure.
Journal ArticleDOI
Carboxyfullerenes as neuroprotective agents
Laura L. Dugan,Dorothy M. Turetsky,Cheng Du,Doug Lobner,Mark E. Wheeler,C. Robert Almli,Clifton K.-F. Shen,Tien-Yau Luh,Dennis W. Choi,Tien-Sung Lin +9 more
TL;DR: Data suggest that polar carboxylic acid C60 derivatives may have attractive therapeutic properties in several acute or chronic neurodegenerative diseases.
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Mediation of neuronal apoptosis by enhancement of outward potassium current.
Shan Ping Yu,Chen Hsiung Yeh,Stefano L. Sensi,Byoung Joo Gwag,Lorella M.T. Canzoniero,Z. Shadi Farhangrazi,Howard S. Ying,Min Tian,Laura L. Dugan,Dennis W. Choi +9 more
TL;DR: Attenuating outward K+ current with tetraethylammonium or elevated extracellular K+, but not blockers of Ca2+, Cl-, or other K+ channels, reduced apoptosis, even if associated increases in intracellular Ca2+ concentration were prevented.
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Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase
M. Margarita Behrens,Sameh S. Ali,Diep N. Dao,Jacinta Lucero,Grigoriy Shekhtman,Kevin L. Quick,Laura L. Dugan +6 more
TL;DR: It is shown that exposure of mice to ketamine induced a persistent increase in brain superoxide due to activation in neurons of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which suggests that NADPH oxidase may represent a novel target for the treatment of ketamine-induced psychosis.
Journal ArticleDOI
Early elevation of cochlear reactive oxygen species following noise exposure.
TL;DR: These ROS measures extend previous results indicating that noise-induced PTS is associated with elevated cochlear ROS production and ROS-mediated injury, and suggests a sustained process of oxidative stress which might be amenable to intervention with chronic antioxidant therapy.