S
Steven M. Rothman
Researcher at Washington University in St. Louis
Publications - 69
Citations - 9141
Steven M. Rothman is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: NMDA receptor & GABAA receptor. The author has an hindex of 35, co-authored 69 publications receiving 8972 citations. Previous affiliations of Steven M. Rothman include University of Washington & St. Louis Children's Hospital.
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Journal ArticleDOI
Glutamate and the pathophysiology of hypoxic--ischemic brain damage.
Steven M. Rothman,John W. Olney +1 more
TL;DR: In this paper, it was shown that either blockade of synaptic transmission or specific antagonism of postsynaptic glutamate receptors greatly diminishes the sensitivity of central neurons to hypoxia and ischemia.
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Excitotoxity and the NMDA receptor
Steven M. Rothman,John W. Olney +1 more
TL;DR: Evidence is accumulating that the brain damage associated with anoxia, stroke, hypoglycemia, epilepsy, and perhaps neurodegenerative illnesses such as Huntington's disease may be at least partially produced by excessive activation of NMDA receptors.
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Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate
Laura L. Dugan,Stefano L. Sensi,Lorella M.T. Canzoniero,Shawn D. Handran,Steven M. Rothman,T. S. Lin,Mark P. Goldberg,Dennis W. Choi +7 more
TL;DR: Data support the possibility that NMDA receptor-mediated, Ca(2+)-dependent uncoupling of neuronal mitochondrial electron transport may contribute to the oxidative stress initiated by glutamate exposure.
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Excitotoxicity and the NMDA receptor - still lethal after eight years
Steven M. Rothman,John W. Olney +1 more
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Synaptic activity mediates death of hypoxic neurons
TL;DR: Observations suggest that damage in hypoxic neurons is mediated by synaptic activity, and cell death could be prevented by treatment with magnesium, which eliminates synaptic activity.