Laura Richter

TL;DR: Methods to use dermal fibroblasts easily obtained from an individual human to generate human induced pluripotent stem (iPS) cells by ectopic expression of the defined transcription factors KLF4, OCT4, SOX2, and C-MYC are described.

TL;DR: Genome-wide data and high-resolution array profiling demonstrated that there is no common specific subkaryotypic alteration that is required for reprograming and that reprogramming does not lead to genomic instability, and suggest that iPSCs should be considered a unique subtype of pluripotent cell.

TL;DR: These findings demonstrate the feasibility of using iPS‐derived motor neuron progenitors and motor neurons in regenerative medicine applications and in vitro modeling of motor neuron diseases.

TL;DR: The results indicate that triple positive iPGCs derived from pluripotent cells differentiated on hFGS cells correspond to committed first trimester germ cells (before 9 weeks) that have initiated the process of imprint erasure.

TL;DR: It is argued that the similarity with which unique stem cells from different tissues respond to external stimuli suggests that they share functional mechanisms.