L
Laure Ségurel
Researcher at Paris Diderot University
Publications - 35
Citations - 3840
Laure Ségurel is an academic researcher from Paris Diderot University. The author has contributed to research in topics: Population & Microbiome. The author has an hindex of 22, co-authored 35 publications receiving 3139 citations. Previous affiliations of Laure Ségurel include Centre national de la recherche scientifique & University of Chicago.
Papers
More filters
Journal ArticleDOI
Detection and interpretation of shared genetic influences on 42 human traits
TL;DR: A method to identify pairs of traits that have multiple genetic causes in common that show evidence of a causal relationship is developed, and shows evidence that increased body mass index causally increases triglyceride levels.
Journal ArticleDOI
Revisiting an Old Riddle: What Determines Genetic Diversity Levels within Species?
Ellen M. Leffler,Kevin Bullaughey,Daniel R. Matute,Wynn K. Meyer,Laure Ségurel,Aarti Venkat,Peter Andolfatto,Molly Przeworski +7 more
TL;DR: With the recent revolution in sequencing, the unresolved question of what influences the range and values of genetic diversity across taxa is revisited.
Journal ArticleDOI
Determinants of Mutation Rate Variation in the Human Germline
TL;DR: It is now feasible to count de novo mutations in transmissions from parents to offspring, and this direct approach yields a mutation rate that is twofold lower than previous estimates, calling into question the authors' understanding of the chronology of human evolution and raising the possibility that mutation rates have evolved relatively rapidly.
Journal ArticleDOI
Multiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees
Ellen M. Leffler,Ziyue Gao,Susanne P. Pfeifer,Laure Ségurel,Laure Ségurel,Adam Auton,Oliver Venn,Rory Bowden,Ronald E. Bontrop,Jeffrey D. Wall,Guy Sella,Peter Donnelly,Gilean McVean,Molly Przeworski,Molly Przeworski +14 more
TL;DR: Findings indicate that ancient balancing selection has shaped human variation and point to genes involved in host-pathogen interactions as common targets.
Journal ArticleDOI
A Fine-Scale Chimpanzee Genetic Map from Population Sequencing
Adam Auton,Adam Auton,Adi Fledel-Alon,Susanne P. Pfeifer,Oliver Venn,Laure Ségurel,Laure Ségurel,Teresa L Street,Ellen M. Leffler,Rory Bowden,Rory Bowden,Ivy Aneas,John Broxholme,Peter Humburg,Zamin Iqbal,Gerton Lunter,Julian Maller,Julian Maller,Ryan D. Hernandez,Cord Melton,Aarti Venkat,Aarti Venkat,Marcelo A. Nobrega,Ronald E. Bontrop,Simon Myers,Simon Myers,Peter Donnelly,Peter Donnelly,Molly Przeworski,Molly Przeworski,Gil McVean,Gil McVean +31 more
TL;DR: A fine-scale genetic map of the Western chimpanzee is constructed from high-throughput sequence data and shows that chimpanzee recombination is dominated by hotspots, which show no overlap with those of humans even though rates are similarly elevated around CpG islands and decreased within genes.