J
Jimmy Z. Liu
Researcher at Biogen Idec
Publications - 54
Citations - 9604
Jimmy Z. Liu is an academic researcher from Biogen Idec. The author has contributed to research in topics: Genome-wide association study & Genetic association. The author has an hindex of 29, co-authored 53 publications receiving 7619 citations. Previous affiliations of Jimmy Z. Liu include Wellcome Trust Sanger Institute & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Jimmy Z. Liu,S van Sommeren,Hailiang Huang,Siew C. Ng,Rudi Alberts,Atsushi Takahashi,Stephan Ripke,James Lee,Luke Jostins,Tejas Shah,Shifteh Abedian,Jae Hee Cheon,Judy H. Cho,N E Dayani,Lude Franke,Yuta Fuyuno,Ailsa L. Hart,Ramesh C. Juyal,Garima Juyal,Won Ho Kim,Andrew P. Morris,Hossein Poustchi,William G. Newman,Vandana Midha,Timothy R. Orchard,H Vahedi,Ajit Sood,J Y Sung,Reza Malekzadeh,Westra H-J.,Keiko Yamazaki,Yang S-K.,Jeffrey C. Barrett,Behrooz Z. Alizadeh,Miles Parkes,T Bk,Mark J. Daly,Michiaki Kubo,Carl A. Anderson,Rinse K. Weersma +39 more
TL;DR: The first trans-ancestry association study of IBD is reported, with genome-wide or Immunochip genotype data from an extended cohort of 86,640 European individuals and immunochip data from 9,846 individuals of East Asian, Indian or Iranian descent, implicate 38 loci in IBD risk for the first time.
Journal ArticleDOI
Detection and interpretation of shared genetic influences on 42 human traits
TL;DR: A method to identify pairs of traits that have multiple genetic causes in common that show evidence of a causal relationship is developed, and shows evidence that increased body mass index causally increases triglyceride levels.
Journal ArticleDOI
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Aysu Okbay,Bart M. L. Baselmans,Jan-Emmanuel De Neve,Patrick Turley,Michel G. Nivard,Mark Alan Fontana,S. Fleur W. Meddens,S. Fleur W. Meddens,S. Fleur W. Meddens,Richard Karlsson Linnér,Richard Karlsson Linnér,Richard Karlsson Linnér,Cornelius A. Rietveld,Jaime Derringer,Jacob Gratten,James J. Lee,Jimmy Z. Liu,Ronald de Vlaming,Tarunveer S. Ahluwalia,Tarunveer S. Ahluwalia,Jadwiga Buchwald,Alana Cavadino,Alexis C. Frazier-Wood,Nicholas A. Furlotte,Victoria Garfield,Marie Henrike Geisel,Juan R. González,Saskia Haitjema,Robert Karlsson,Sander W. van der Laan,Karl-Heinz Ladwig,Jari Lahti,Sven J. van der Lee,Penelope A. Lind,Tian Liu,Lindsay K. Matteson,Evelin Mihailov,Michael B. Miller,Camelia C. Minică,Ilja M. Nolte,Dennis O. Mook-Kanamori,Peter J. van der Most,Christopher Oldmeadow,Yong Qian,Olli T. Raitakari,Olli T. Raitakari,Rajesh Rawal,Anu Realo,Anu Realo,Rico Rueedi,Rico Rueedi,Börge Schmidt,Albert V. Smith,Evie Stergiakouli,Toshiko Tanaka,Kent D. Taylor,Gudmar Thorleifsson,Juho Wedenoja,Juergen Wellmann,Harm-Jan Westra,Sara M. Willems,Wei Zhao,Najaf Amin,Andrew Bakshi,Sven Bergmann,Sven Bergmann,Gyda Bjornsdottir,Patricia A. Boyle,Samantha Cherney,Simon R. Cox,Gail Davies,Oliver S. P. Davis,Jun Ding,Nese Direk,Peter Eibich,Peter Eibich,Rebecca T. Emeny,Ghazaleh Fatemifar,Jessica D. Faul,Luigi Ferrucci,Andreas J. Forstner,Christian Gieger,Richa Gupta,Tamara B. Harris,Juliette Harris,Elizabeth G. Holliday,Jouke-Jan Hottenga,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Marika Kaakinen,Marika Kaakinen,Eero Kajantie,Eero Kajantie,Ville Karhunen,Ivana Kolcic,Meena Kumari,Lenore J. Launer,Lude Franke,Ruifang Li-Gao,David C. Liewald,Marisa Koini,Anu Loukola,Pedro Marques-Vidal,Grant W. Montgomery,Miriam A. Mosing,Lavinia Paternoster,Alison Pattie,K. Petrovic,Laura Pulkki-Råback,Lydia Quaye,Katri Räikkönen,Igor Rudan,Rodney J. Scott,Jennifer A. Smith,Angelina R. Sutin,Angelina R. Sutin,Maciej Trzaskowski,Maciej Trzaskowski,Anna A. E. Vinkhuyzen,Lei Yu,Delilah Zabaneh,John Attia,David A. Bennett,Klaus Berger,Lars Bertram,Lars Bertram,Dorret I. Boomsma,Harold Snieder,Shun-Chiao Chang,Francesco Cucca,Ian J. Deary,Cornelia M. van Duijn,Johan G. Eriksson,Johan G. Eriksson,Ute Bültmann,Eco J. C. de Geus,Patrick J. F. Groenen,Vilmundur Gudnason,Torben Hansen,C.A. Hartman,Claire M. A. Haworth,Caroline Hayward,Andrew C. Heath,David A. Hinds,Elina Hyppönen,Elina Hyppönen,William G. Iacono,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Jaakko Kaprio,Jaakko Kaprio,Sharon L.R. Kardia,Liisa Keltikangas-Järvinen,Peter Kraft,Laura D. Kubzansky,Terho Lehtimäki,Patrik K. E. Magnusson,Nicholas G. Martin,Matt McGue,Andres Metspalu,Melinda Mills,Renée de Mutsert,Albertine J. Oldehinkel,Gerard Pasterkamp,Nancy L. Pedersen,Robert Plomin,Ozren Polasek,Christine Power,Stephen S. Rich,Frits R. Rosendaal,Hester M. den Ruijter,David Schlessinger,Helena Schmidt,Rauli Svento,Reinhold Schmidt,Behrooz Z. Alizadeh,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Tim D. Spector,John M. Starr,Kari Stefansson,Kari Stefansson,Andrew Steptoe,Antonio Terracciano,Antonio Terracciano,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Roy Thurik,Nicholas J. Timpson,Henning Tiemeier,André G. Uitterlinden,Peter Vollenweider,Gert G. Wagner,Gert G. Wagner,Gert G. Wagner,David R. Weir,Jian Yang,Dalton Conley,George Davey Smith,Albert Hofman,Albert Hofman,Magnus Johannesson,David Laibson,Sarah E. Medland,Michelle N. Meyer,Michelle N. Meyer,Joseph K. Pickrell,Tõnu Esko,Robert F. Krueger,Jonathan P. Beauchamp,Philipp Koellinger,Philipp Koellinger,Philipp Koellinger,Daniel J. Benjamin,Meike Bartels,David Cesarini +216 more
TL;DR: In this paper, the authors conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n= 161,460), and neuroticism(n = 170,911).
Journal ArticleDOI
A versatile gene-based test for genome-wide association studies
Jimmy Z. Liu,Allan F. McRae,Dale R. Nyholt,Sarah E. Medland,Naomi R. Wray,Kevin M. Brown,Nicholas K. Hayward,Grant W. Montgomery,Peter M. Visscher,Nicholas G. Martin,Stuart MacGregor +10 more
TL;DR: This work derived a versatile gene-based test for genome-wide association studies (GWAS) that has the potential to identify novel associated genes; provide a basis for selecting SNPs for replication; and be directly used in network (pathway) approaches that require per-gene association test statistics.
Journal ArticleDOI
Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned
Naomi R. Wray,Michele L. Pergadia,Douglas Blackwood,Brenda W.J.H. Penninx,Scott D. Gordon,Dale R. Nyholt,Stephan Ripke,Stephan Ripke,Donald J. MacIntyre,Kevin A. McGhee,Alan W Maclean,Jan H. Smit,Jouke-Jan Hottenga,Gonneke Willemsen,Christel M. Middeldorp,E.J.C. de Geus,Cathryn M. Lewis,Peter McGuffin,Ian B. Hickie,E. J. C. G. van den Oord,Jimmy Z. Liu,Stuart MacGregor,Brian P. McEvoy,Enda M. Byrne,Sarah E. Medland,Dixie J. Statham,Dixie J. Statham,Anjali K. Henders,A. C. Heath,Grant W. Montgomery,Nicholas G. Martin,Dorret I. Boomsma,Pa Madden,Patrick F. Sullivan +33 more
TL;DR: This paper conducted a genome-wide association study of the MDD2000þ sample (2431 cases, 3673 screened controls and > 1M imputed single-nucleotide polymorphisms (SNPs).