L
Lauren D. Palmer
Researcher at Vanderbilt University Medical Center
Publications - 27
Citations - 859
Lauren D. Palmer is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Acinetobacter baumannii & Virulence. The author has an hindex of 13, co-authored 24 publications receiving 593 citations. Previous affiliations of Lauren D. Palmer include Vanderbilt University & Florida State University College of Arts and Sciences.
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Journal ArticleDOI
Transition Metals and Virulence in Bacteria
TL;DR: This review focuses on recent advances and open questions in the understanding of the complex role of transition metals at the host-pathogen interface.
Journal ArticleDOI
Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes
Gisela Di Venanzio,Ana L. Flores-Mireles,Ana L. Flores-Mireles,Juan J Calix,M. Florencia Haurat,Nichollas E. Scott,Lauren D. Palmer,Robert F. Potter,Michael E. Hibbing,Laura E. Friedman,Bin Wang,Gautam Dantas,Eric P. Skaar,Scott J. Hultgren,Mario F. Feldman +14 more
TL;DR: A mouse model of catheter-associated urinary tract infection is developed and it is shown that a plasmid confers niche specificity to an A. baumannii urinary isolate by regulating the expression of chromosomal genes, demonstrating that plasmids can impact bacterial infections by controlling theexpression of chromosomesomal genes.
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Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S-Sulfhydration and Global Virulence Regulation in Staphylococcus aureus.
Hui Peng,Yixiang Zhang,Lauren D. Palmer,Thomas E. Kehl-Fie,Eric P. Skaar,Jonathan C. Trinidad,David P. Giedroc +6 more
TL;DR: It is shown that the human pathogen Staphylococcus aureus harbors a pool of proteome- and metabolite-derived RSS capable of impacting protein activities and gene regulation and that H2S signaling can be sensed by global regulators to affect the expression of virulence factors.
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Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus.
Hui Peng,Jiangchuan Shen,Katherine A. Edmonds,Justin L. Luebke,Anne K. Hickey,Lauren D. Palmer,Feng-Ming James Chang,Kevin A. Bruce,Thomas E. Kehl-Fie,Thomas E. Kehl-Fie,Eric P. Skaar,David P. Giedroc +11 more
TL;DR: An H2S/NO· interplay in S. aureus that impacts transition metal homeostasis and virulence gene expression is revealed and is traced to a direct reaction of CstR with HNO and to an endogenous perturbation in cellular RSS, possibly originating from disassembly of Fe-S clusters.
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Medically Relevant Acinetobacter Species Require a Type II Secretion System and Specific Membrane-Associated Chaperones for the Export of Multiple Substrates and Full Virulence.
TL;DR: Using bioinformatics, proteomics, and mutational analyses, it is demonstrated that Acinetobacter nosocomialis strain M2 produces a functional T2SS, which is required for full virulence in both the Galleria mellonella and murine pulmonary infection models.