L
Lauren Murphy
Researcher at University of Texas Health Science Center at Houston
Publications - 33
Citations - 1865
Lauren Murphy is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Chronic traumatic encephalopathy & Genetic counseling. The author has an hindex of 14, co-authored 33 publications receiving 1403 citations. Previous affiliations of Lauren Murphy include University of Texas at Austin & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football
Jesse Mez,Daniel H. Daneshvar,Patrick T. Kiernan,Bobak Abdolmohammadi,Victor E. Alvarez,Bertrand R. Huber,Michael L. Alosco,Todd M. Solomon,Christopher J. Nowinski,Lisa McHale,Kerry Cormier,Caroline A. Kubilus,Brett M. Martin,Lauren Murphy,Christine M. Baugh,Phillip H. Montenigro,Christine E. Chaisson,Yorghos Tripodis,Neil W. Kowall,Jennifer Weuve,Michael D. McClean,Robert C. Cantu,Lee E. Goldstein,Douglas I. Katz,Robert S. Stern,Thor D. Stein,Ann C. McKee +26 more
TL;DR: In a convenience sample of deceased football players who donated their brains for research, a high proportion had neuropathological evidence of CTE, suggesting that CTE may be related to prior participation in football.
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Beta-amyloid deposition in chronic traumatic encephalopathy
Thor D. Stein,Thor D. Stein,Thor D. Stein,Philip H. Montenigro,Victor E. Alvarez,Weiming Xia,John F. Crary,Yorghos Tripodis,Daniel H. Daneshvar,Jesse Mez,Todd M. Solomon,Gaoyuan Meng,Caroline A. Kubilus,Kerry Cormier,Steven Meng,Katharine J. Babcock,Patrick T. Kiernan,Lauren Murphy,Christopher J. Nowinski,Brett Martin,Diane Dixon,Robert S. Stern,Robert C. Cantu,Robert C. Cantu,Neil W. Kowall,Neil W. Kowall,Ann C. McKee,Ann C. McKee,Ann C. McKee +28 more
TL;DR: The findings suggest that A β deposition is altered and accelerated in a cohort of CTE subjects compared to normal aging and that Aβ is associated with both pathological and clinical progression of Cte independent of age.
Journal ArticleDOI
Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations
Michelle Vaz,Stephen Y. Hwang,Ioannis Kagiampakis,Jillian Phallen,Ashwini Patil,Heather M. O'Hagan,Lauren Murphy,Cynthia A. Zahnow,Edward Gabrielson,Victor E. Velculescu,Hariharan Easwaran,Stephen B. Baylin +11 more
TL;DR: Chronic cigarette smoke-induced time-dependent epigenetic alterations can sensitize human bronchial epithelial cells for transformation by a single oncogene involved in lung cancer initiation, and these cells transform by introducing a single KRAS mutation and form adenosquamous lung carcinomas in mice.
Journal ArticleDOI
Age of first exposure to tackle football and chronic traumatic encephalopathy.
Michael L. Alosco,Jesse Mez,Yorghos Tripodis,Patrick T. Kiernan,Bobak Abdolmohammadi,Lauren Murphy,Neil W. Kowall,Neil W. Kowall,Thor D. Stein,Bertrand R. Huber,Bertrand R. Huber,Lee E. Goldstein,Robert C. Cantu,Douglas I. Katz,Christine E. Chaisson,Brett Martin,Todd M. Solomon,Michael D. McClean,Daniel H. Daneshvar,Christopher J. Nowinski,Robert S. Stern,Ann C. McKee +21 more
TL;DR: To examine the effect of age of first exposure to tackle football on chronic traumatic encephalopathy (CTE) pathological severity and age of neurobehavioral symptom onset in tackle football players with neuropathologically confirmed CTE, data are presented on players aged between 18 and 29.
Journal ArticleDOI
Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study
Jesse Mez,Todd M. Solomon,Daniel H. Daneshvar,Lauren Murphy,Patrick T. Kiernan,Philip H. Montenigro,Joshua Kriegel,Bobak Abdolmohammadi,Brian Fry,Katharine J. Babcock,Jason W. Adams,Alexandra P. Bourlas,Zachary Papadopoulos,Lisa McHale,Brent M. Ardaugh,Brett Martin,Diane Dixon,Christopher J. Nowinski,Christine E. Chaisson,Victor E. Alvarez,Yorghos Tripodis,Thor D. Stein,Lee E. Goldstein,Douglas I. Katz,Neil W. Kowall,Robert C. Cantu,Robert S. Stern,Ann C. McKee +27 more
TL;DR: The UNITE study is a novel and methodologically rigorous means of assessing clinicopathological correlation in CTE, and its findings will be critical for developing future iterations of CTE clinical diagnostic criteria.