Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21
Takeshi Inagaki,Paul A. Dutchak,Guixiang Zhao,Xunshan Ding,Laurent Gautron,Vinay Parameswara,Yong Li,Regina Goetz,Moosa Mohammadi,Victoria Esser,Joel K. Elmquist,Robert D. Gerard,Shawn C. Burgess,Robert E. Hammer,David J. Mangelsdorf,Steven A. Kliewer +15 more
TLDR
These findings demonstrate an unexpected role for the PPARalpha-FGF21 endocrine signaling pathway in regulating diverse metabolic and behavioral aspects of the adaptive response to starvation.About:
This article is published in Cell Metabolism.The article was published on 2007-06-06 and is currently open access. It has received 1374 citations till now. The article focuses on the topics: FGF21 & Energy source.read more
Citations
More filters
Journal ArticleDOI
The FGF family: biology, pathophysiology and therapy.
Andrew Beenken,Moosa Mohammadi +1 more
TL;DR: Traditional applications of recombinant FGFs and small-molecule FGF receptor kinase inhibitors in the treatment of cancer and cardiovascular disease and their emerging potential in thetreatment of metabolic syndrome and hypophosphataemic diseases are discussed.
Journal ArticleDOI
The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TL;DR: Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.
OtherDOI
Energy metabolism in the liver
TL;DR: The liver is an essential metabolic organ, and its metabolic function is controlled by insulin and other metabolic hormones, so controlling liver energy metabolism is tightly regulated by neuronal and hormonal signals.
Journal ArticleDOI
Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States
Michael K. Badman,Pavlos Pissios,Adam R. Kennedy,George Koukos,Jeffrey S. Flier,Eleftheria Maratos-Flier +5 more
TL;DR: Induction of FGF21 in liver is required for the normal activation of hepatic lipid oxidation, triglyceride clearance, and ketogenesis induced by KD, and a physiological role for this hepatic hormone is identified.
Journal ArticleDOI
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
ffolliott M. Fisher,Sandra Kleiner,Nicholas Douris,Elliott C. Fox,Rina J. Mepani,Francisco Verdeguer,Jun Wu,Alexei Kharitonenkov,Jeffrey S. Flier,Eleftheria Maratos-Flier,Bruce M. Spiegelman +10 more
TL;DR: It is shown here that fibroblast growth factor 21 (FGF21) plays a physiologic role in this thermogenic recruitment of WATs and acts to activate and expand the thermogenic machinery in vivo to provide a robust defense against hypothermia.
References
More filters
Journal ArticleDOI
A simple method for the isolation and purification of total lipides from animal tissues.
TL;DR: In this paper, the authors described a simplified version of the method and reported the results of a study of its application to different tissues, including the efficiency of the washing procedure in terms of the removal from tissue lipides of some non-lipide substances of special biochemical interest.
Journal ArticleDOI
FGF-21 as a novel metabolic regulator
Alexei Kharitonenkov,Tatiyana L. Shiyanova,Anja Koester,Amy M. Ford,Radmila Micanovic,Elizabeth Galbreath,George E. Sandusky,Lisa Janine Hammond,Julie S. Moyers,Owens Rebecca Anne,Jesper Gromada,Joseph T. Brozinick,Eric D. Hawkins,Victor J. Wroblewski,De Shan Li,Farrokh Mehrbod,S. Richard Jaskunas,Armen B. Shanafelt +17 more
TL;DR: It is concluded that FGF-21, which was discovered to be a potent regulator of glucose uptake in mouse 3T3-L1 and primary human adipocytes, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.
Journal ArticleDOI
Roles of PPARs in health and disease.
TL;DR: The latest developments in the PPAR field are presented, with particular emphasis on the physiological function ofPPARs during various nutritional states, and the possible role of PPARs in several chronic diseases.
Journal ArticleDOI
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Takeshi Inagaki,Mihwa Choi,Antonio Moschetta,Li Peng,Carolyn L. Cummins,Jeffrey G. McDonald,Guizhen Luo,Stacey A. Jones,Bryan Goodwin,James A. Richardson,Robert D. Gerard,Joyce J. Repa,David J. Mangelsdorf,Steven A. Kliewer +13 more
TL;DR: It is demonstrated that fibroblast growth factor 15 signals from intestine to liver to repress the gene encoding cholesterol 7alpha-hydroxylase (CYP7A1), which catalyzes the first and rate-limiting step in the classical bile acid synthetic pathway.
Journal ArticleDOI
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Sander Kersten,Josiane Seydoux,Jeffrey M. Peters,Frank J. Gonzalez,Béatrice Desvergne,Walter Wahli +5 more
TL;DR: It is shown that to accommodate the increased requirement for hepatic fatty acid oxidation, PPAR α mRNA is induced during fasting in wildtype mice, indicating that PPARα plays a pivotal role in the management of energy stores during fasting.
Related Papers (5)
FGF-21 as a novel metabolic regulator
Alexei Kharitonenkov,Tatiyana L. Shiyanova,Anja Koester,Amy M. Ford,Radmila Micanovic,Elizabeth Galbreath,George E. Sandusky,Lisa Janine Hammond,Julie S. Moyers,Owens Rebecca Anne,Jesper Gromada,Joseph T. Brozinick,Eric D. Hawkins,Victor J. Wroblewski,De Shan Li,Farrokh Mehrbod,S. Richard Jaskunas,Armen B. Shanafelt +17 more