Xunshan Ding

TL;DR: These findings demonstrate an unexpected role for the PPARalpha-FGF21 endocrine signaling pathway in regulating diverse metabolic and behavioral aspects of the adaptive response to starvation.

TL;DR: It is shown that fibroblast growth factor 21 (FGF21), a hormone that is induced in liver by fasting, induces hepatic expression of peroxisome proliferator-activated receptor γ coactivator protein-1 α (PGC-1α), a key transcriptional regulator of energy homeostasis, and causes corresponding increases in fatty acid oxidation, tricarboxylic acid cycle flux, and gluconeogenesis without increasing glycogenolysis.

TL;DR: This FGF atlas provides an important resource for guiding future studies to elucidate the physiological functions of FGFs in adult animals and shows that the most recently identified Klotho family member, Lactase-like, is highly and selectively expressed in brown adipose tissue and eye and can function as an additional coreceptor for FGF19.

TL;DR: A crucial role for the nervous system is demonstrated in mediating the diverse physiologic and pharmacologic actions of FGF21, which increases systemic glucocorticoid levels, suppresses physical activity and alters circadian behavior, which are all features of the adaptive starvation response.

TL;DR: It is reported that FGF21 acts centrally to exert its effects on energy expenditure and body weight in obese mice, and it is shown that βKlotho, the obligate coreceptor for FGF 21, is required in the nervous system for these effects.