Lavinia Maegel

TL;DR: Consistently, in vivo and in vitro, rAAT reduced inflammatory responses at concentrations 40- to 100-fold lower than native plasma-derived AAT, providing evidence that the anti-inflammatory and immunomodulatory properties of AAT can be independent of elastase inhibition.

TL;DR: It is shown that activation of the peroxisome proliferator–activated receptor γ (PPARγ) via pioglitazone treatment protects against heart failure in the Sugen hypoxia rat model of pulmonary arterial hypertension and suggests that targeting PPARγ activation to restore fatty acid oxidation could be therapeutic for pulmonary hypertension and other diseases with altered lipid metabolism.

TL;DR: PLs show a distinct cellular composition and microenvironment, which contribute to the plexiform phenotype and set them apart from other processes of vascular remodeling in patients with PAH.

TL;DR: Ang-2 may be involved in the pathogenesis of IPAH, and plasma Ang-2 might serve as a promising new biomarker of disease severity and response to treatment in patients with IPAH.

TL;DR: It is concluded that Notch1 plays a critical role in PAH and Notch inhibitors may be a promising therapeutic option for PAH.