Danny Jonigk

TL;DR: In this small series, vascular angiogenesis distinguished the pulmonary pathobiology of Covid-19 from that of equally severe influenza virus infection.

TL;DR: In this article, the authors showed that several TMPRSS2-related proteases activate SARS-CoV-2 and that two of them are robustly expressed in the upper respiratory tract and can be blocked by Camostat mesylate and its metabolite GBPA.

TL;DR: Consistently, in vivo and in vitro, rAAT reduced inflammatory responses at concentrations 40- to 100-fold lower than native plasma-derived AAT, providing evidence that the anti-inflammatory and immunomodulatory properties of AAT can be independent of elastase inhibition.

TL;DR: It is shown that activation of the peroxisome proliferator–activated receptor γ (PPARγ) via pioglitazone treatment protects against heart failure in the Sugen hypoxia rat model of pulmonary arterial hypertension and suggests that targeting PPARγ activation to restore fatty acid oxidation could be therapeutic for pulmonary hypertension and other diseases with altered lipid metabolism.

TL;DR: PLs show a distinct cellular composition and microenvironment, which contribute to the plexiform phenotype and set them apart from other processes of vascular remodeling in patients with PAH.