Lawrence A. Leiter

TL;DR: In this phase 2, multicenter, double‐blind, placebo‐controlled, multiple‐ascending‐dose trial of inclisiran administered as a subcutaneous injection in patients at high risk for cardiovascular disease who had elevated LDL cholesterol levels, inclisIRan was found to lower PCSK9 and LDL cholesterol Levels among patients athigh cardiovascular risk.

TL;DR: All individuals with hypertension should have an assessment of global cardiovascular risk to promote health behaviours that lower blood pressure, and an angiotensin receptor-neprilysin inhibitor combination should be used in place of either an ang Elliotensin-converting enzyme inhibitor or angiotENSin receptor blocker in individuals with heart failure.

TL;DR: The evidence-based recommendations for the prevention and treatment of hypertension in adults for 2010 are updated and treatment thresholds and targets should be predicated on the patient's global atherosclerotic risk, target organ damage and comorbid conditions.

TL;DR: In this paper, the effects of low-glycemic index diets on glycemic control and cardiovascular risk factors in patients with type 2 diabetes were evaluated in a randomized, parallel study at a Canadian university hospital research center.

TL;DR: The 1992 edition of the clinical practice guidelines for the management of diabetes in Canada incorporating recent advances in diagnosis and outpatient management of diabetic mellitus and to identify and assess the evidence supporting these recommendations were reviewed, revised as required and expressed as a set of recommendations as discussed by the authors.