Lawrence A. Quilliam

TL;DR: It is shown that caveolin interacts with another well characterized signal transducer, Ras, and that recombinant overexpression of caveolin in intact cells is sufficient to functionally recruit a nonfarnesylated mutant of Ras onto membranes, overcoming the normal requirement for lipid modification of Ras.

TL;DR: Data indicate that Cys118 is a critical site of redox regulation of p21(ras), and S-nitrosylation of this residue triggers guanine nucleotide exchange and downstream signaling.

TL;DR: The ability of Rheb to induce S6 phosphorylation was also inhibited by a farnesyl transferase inhibitor, suggesting that RheB may be responsible for the Ras-independent anti-neoplastic properties of this drug.

TL;DR: This study probed cross-talk between cAMP signaling and the phosphatidylinositol 3-kinase/PKB pathways by monitoring the specific roles that Epac and PKA play individually in regulating PKB activity and suggests a complex regulatory scheme in which Epacand PKA mediate the opposing effects of cAMP on PKB regulation.