L
Lawrence D. Gaspers
Researcher at Rutgers University
Publications - 35
Citations - 2072
Lawrence D. Gaspers is an academic researcher from Rutgers University. The author has contributed to research in topics: Mitochondrion & Calcium signaling. The author has an hindex of 18, co-authored 35 publications receiving 1932 citations. Previous affiliations of Lawrence D. Gaspers include University of Medicine and Dentistry of New Jersey & University of South Dakota.
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Journal ArticleDOI
Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34
Pawan Gulati,Lawrence D. Gaspers,Stephen G. Dann,Manel Joaquin,Takahiro Nobukuni,Francois Natt,Sara C. Kozma,Andrew P. Thomas,George Thomas +8 more
TL;DR: It is shown that AAs induce a rise in intracellular Ca(2+) ([Ca(2+)](i), which triggers mTOR Complex 1 and hVps34 activation, which increases the direct binding of Ca( 2+)/calmodulin (CaM) to an evolutionarily conserved motif in hVPS34 that is required for lipid kinase activity and increased mTOR complex 1 signaling.
Journal ArticleDOI
Glucokinase is the likely mediator of glucosensing in both glucose-excited and glucose-inhibited central neurons.
TL;DR: A critical role is suggested for GK as a regulator of glucosensing in both GE and GI neurons in the brain.
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Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons
TL;DR: Although GK may mediate glucosensing in up to 60% of VMN neurons, other regulatory mechanisms are likely to control glucos sensing in the remaining ones.
Journal ArticleDOI
Glucokinase Is a Critical Regulator of Ventromedial Hypothalamic Neuronal Glucosensing
Ling Kang,Ambrose A. Dunn-Meynell,Ambrose A. Dunn-Meynell,Vanessa H. Routh,Lawrence D. Gaspers,Yasufumi Nagata,Teruyuki Nishimura,Jun-ichi Eiki,Bei B. Zhang,Barry E. Levin,Barry E. Levin +10 more
TL;DR: Data supported a critical role for glucokinase in neuronal glucosensing by showing that glucose-induced changes in intracellular Ca(2+) concentration ([Ca(2+)](i) oscillations were highly correlated in both glucose-excited and -inhibited neurons.
Journal ArticleDOI
Models of IP3 and Ca2+ Oscillations: Frequency Encoding and Identification of Underlying Feedbacks
TL;DR: The ectopic expression of an IP3 binding protein has been used to decrease the rate of IP3 turnover experimentally, resulting in a dose-dependent slowing and eventual quenching of the Ca2+ oscillations, consistent with a model based on positive feedback of Ca2- on IP3 production.