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Francois Natt
Researcher at Novartis
Publications - 87
Citations - 5784
Francois Natt is an academic researcher from Novartis. The author has contributed to research in topics: Oligonucleotide & RNA interference. The author has an hindex of 31, co-authored 87 publications receiving 5612 citations. Previous affiliations of Francois Natt include Friedrich Miescher Institute for Biomedical Research & Northwestern University.
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Journal ArticleDOI
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
Takahiro Nobukuni,Manel Joaquin,Manel Joaquin,Marta Roccio,Stephen G. Dann,So Young Kim,Pawan Gulati,Maya P. Byfield,Jonathan M. Backer,Francois Natt,Johannes L. Bos,Fried J. T. Zwartkruis,George Thomas,George Thomas +13 more
TL;DR: A major pathway by which amino acids control mTOR signaling is distinct from that of insulin and that, instead of signaling through components of the insulin/class 1PI3K pathway, amino acids mediate mTOR activation by signaling through class 3 PI3K, hVps34.
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The mTOR Inhibitor RAD001 Sensitizes Tumor Cells to DNA-Damaged Induced Apoptosis through Inhibition of p21 Translation
Iwan Beuvink,Anne Boulay,Stefano Fumagalli,Frederic Zilbermann,Stephan Ruetz,Terence O'reilly,Francois Natt,Jonathan Hall,Heidi Lane,George Thomas +9 more
TL;DR: It is shown that RAD001 (everolimus), a rapamycin derivative, dramatically enhances cisplatin-induced apoptosis in wild-type p53, but not mutant p53 tumor cells, showing that a general effect on a major anabolic process may dramatically enhance the efficacy of an established drug protocol in the treatment of cancer patients with solid tumors.
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siRNA relieves chronic neuropathic pain
Gabriele Dorn,Sadhana Patel,Glen Wotherspoon,Maja Hemmings-Mieszczak,Jane Barclay,Francois Natt,Pierre Martin,Stuart Bevan,Alyson Fox,Pam Ganju,William Leonard Wishart,Jonathan Hall +11 more
TL;DR: It is shown that RNAi can block a pathophysiological pain response and provide relief from neuropathic pain in a rat disease model by down regulating an endogenous, neuronally expressed gene.
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Design of a genome-wide siRNA library using an artificial neural network.
Dieter Huesken,Joerg Lange,Craig Mickanin,Jan Weiler,Fred A.M. Asselbergs,Justin Warner,Brian Meloon,Sharon Engel,Avi Rosenberg,Dalia Cohen,Mark Labow,Mischa Reinhardt,Francois Natt,Jonathan Hall +13 more
TL;DR: The Stuttgart Neural Net Simulator was used to train algorithms on a data set of 2,182 randomly selected siRNAs targeted to 34 mRNA species, assayed through a high-throughput fluorescent reporter gene system and BIOPREDsi was used in the design of a genome-wide siRNA collection with two potent si RNAs per gene.
Journal ArticleDOI
Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34
Pawan Gulati,Lawrence D. Gaspers,Stephen G. Dann,Manel Joaquin,Takahiro Nobukuni,Francois Natt,Sara C. Kozma,Andrew P. Thomas,George Thomas +8 more
TL;DR: It is shown that AAs induce a rise in intracellular Ca(2+) ([Ca(2+)](i), which triggers mTOR Complex 1 and hVps34 activation, which increases the direct binding of Ca( 2+)/calmodulin (CaM) to an evolutionarily conserved motif in hVPS34 that is required for lipid kinase activity and increased mTOR complex 1 signaling.