L
Lawrence Karsh
Researcher at Brigham and Women's Hospital
Publications - 99
Citations - 5439
Lawrence Karsh is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Prostate cancer & Medicine. The author has an hindex of 23, co-authored 83 publications receiving 4509 citations.
Papers
More filters
Journal ArticleDOI
Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study
Karim Fizazi,Michael A. Carducci,Matthew R. Smith,Ronaldo Damião,Janet E. Brown,Lawrence Karsh,Piotr Milecki,Neal D. Shore,Michael Rader,H. Wang,Qi Jiang,Sylvia Tadros,Roger Dansey,Carsten Goessl +13 more
TL;DR: Denosumab was better than zoledronic acid for prevention of skeletal-related events, and potentially represents a novel treatment option in men with bone metastases from castration-resistant prostate cancer.
Journal ArticleDOI
Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer : results of a phase 3, randomised, placebo-controlled trial.
Matthew R. Smith,Fred Saad,Robert E. Coleman,Neal D. Shore,Karim Fizazi,Bertrand Tombal,Kurt Miller,Paul Sieber,Lawrence Karsh,Ronaldo Damião,Teuvo L.J. Tammela,Blair Egerdie,Hendrik Van Poppel,Joseph L. Chin,Juan Morote,Francisco Gomez-Veiga,Tomasz Borkowski,Zhishen Ye,Amy Kupic,Roger Dansey,Carsten Goessl +20 more
TL;DR: This large randomised study shows that targeting of the bone microenvironment can delay bone metastasis in men with prostate cancer and significantly increased bone-metastasis-free survival.
Journal ArticleDOI
A Multi-institutional Prospective Trial in the USA Confirms that the 4Kscore Accurately Identifies Men with High-grade Prostate Cancer
Dipen J. Parekh,Sanoj Punnen,Daniel Sjöberg,Scott Asroff,James Bailen,James S. Cochran,Raoul S. Concepcion,Richard D. David,Kenneth B. Deck,Igor Dumbadze,Michael Gambla,Michael S. Grable,Ralph Jonathan Henderson,Lawrence Karsh,Evan B. Krisch,Timothy Dean Langford,Daniel W. Lin,Shawn M. McGee,John J. Munoz,Christopher Michael Pieczonka,Kimberley Rieger-Christ,Daniel Saltzstein,John W. Scott,Neal D. Shore,Paul Sieber,Todd M. Waldmann,Fredrick N. Wolk,Stephen M. Zappala +27 more
TL;DR: The 4Kscore showed excellent diagnostic performance in detecting significant PCa and is a useful tool in selecting men who have significant disease and are most likely to benefit from a prostate biopsy from men with no cancer or indolent cancer.
Journal ArticleDOI
Hydrogel Spacer Prospective Multicenter Randomized Controlled Pivotal Trial: Dosimetric and Clinical Effects of Perirectal Spacer Application in Men Undergoing Prostate Image Guided Intensity Modulated Radiation Therapy
Neil Mariados,John Sylvester,Dhiren Shah,Lawrence Karsh,Richard Hudes,David C. Beyer,Steven Kurtzman,Jeffrey A. Bogart,R. Alex Hsi,Michael Kos,Rodney J. Ellis,Mark Logsdon,S.H. Zimberg,Kevin Forsythe,Hong Zhang,Edward Soffen,Patrick Francke,Constantine Mantz,Peter J. Rossi,Theodore L. DeWeese,Daniel A. Hamstra,Walter Bosch,Jeff M. Michalski +22 more
TL;DR: The spacer appears to be an effective tool, potentially enabling advanced prostate RT protocols, and decreased rates of patients experiencing declines in bowel quality of life.
Journal ArticleDOI
Continued Benefit to Rectal Separation for Prostate Radiation Therapy: Final Results of a Phase III Trial
Daniel A. Hamstra,Neil Mariados,John Sylvester,Dhiren Shah,Lawrence Karsh,Richard Hudes,David C. Beyer,Steven Kurtzman,Jeffrey A. Bogart,R. Alex Hsi,Michael Kos,Rodney J. Ellis,Mark Logsdon,S.H. Zimberg,Kevin Forsythe,Hong Zhang,Edward Soffen,Patrick Francke,Constantine Mantz,Peter J. Rossi,Theodore L. DeWeese,Stephanie Daignault-Newton,Benjamin W. Fischer-Valuck,Anupama Chundury,Walter Bosch,Jeff M. Michalski +25 more
TL;DR: The benefit of a hydrogel spacer in reducing the rectal dose, toxicity, and QOL declines after image guided intensity modulated radiation therapy for prostate cancer was maintained or increased with a longer follow-up period, providing stronger evidence for the benefit of hydrogels spacer use in prostate radiation therapy.