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Showing papers by "Lee Rowen published in 2021"

Journal Article•
Autoantibodies neutralizing type I IFNs are present in similar to 4% of uninfected individuals over 70 years old and account for similar to 20% of COVID-19 deaths

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Paul Bastard, Adrian Gervais, Tom Le Voyer, Jérémie Rosain  +191 more
01 Jan 2021-Science immunology

1 citations

Posted Content•DOI•
Heterogeneous immunological recovery trajectories revealed in post-acute COVID-19

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Yu-Ru Su1, Yu-Ru Su2, Dan Yuan2, Dan Yuan3, Chen Dg2, Kai Wang2, Jongchan Choi2, Chengzhen L. Dai2, Sunga Hong2, Zhang R3, Zhang R2, Jingyi Xie2, Li S2, Kelsey Scherler2, Ana Jimena Pavlovitch-Bedzyk4, Shen Dong5, Christopher Lausted2, Rachel Ng3, Rachel Ng2, Lee I2, Shannon Fallen2, Sergey A. Kornilov2, Priyanka Baloni2, Venkata R Duvvuri2, Anderson Kg1, Anderson Kg3, Jessi W Li4, Fan Yang4, Clifford Rostomily2, Pamela Troisch2, Brett Smith2, Jing Zhou, Sean Mackay, Murry K2, Rick Edmark2, Lesley Jones2, Yong Zhou2, Lee Rowen2, Rachel Liu2, Chour W2, William R. Berrington, Julie A. Wallick, Heather A. Algren, Terri Wrin6, Christos J. Petropoulos6, Wei Wei2, Nathan D. Price2, Naeha Subramanian2, Naeha Subramanian3, Jennifer Hadlock2, Andrew T. Magis2, Antoni Ribas7, Lewis L. Lanier8, Scott D. Boyd4, Jeffrey A. Bluestone5, Leroy Hood2, Raphael Gottardo1, Raphael Gottardo3, Phil Greenberg3, Phil Greenberg1, Mark M. Davis4, Jason D Goldman3, Heath3 •
Fred Hutchinson Cancer Research Center1, Institute for Systems Biology2, University of Washington3, Stanford University4, University of California, Berkeley5, Monogram Biosciences6, University of California, Los Angeles7, University of California, San Francisco8
20 Mar 2021-medRxiv
TL;DR: In this article, the authors investigated 140 COVID-19 patients from diagnosis to convalescence using clinical data, viral load assessments, and multi-omic analyses of blood plasma and circulating immune cells.
Abstract: The immunological picture of how different patients recover from COVID-19, and how those recovery trajectories are influenced by infection severity, remain unclear. We investigated 140 COVID-19 patients from diagnosis to convalescence using clinical data, viral load assessments, and multi-omic analyses of blood plasma and circulating immune cells. Immune-phenotype dynamics resolved four recovery trajectories. One trajectory signals a return to pre-infection healthy baseline, while the other three are characterized by differing fractions of persistent cytotoxic and proliferative T cells, distinct B cell maturation processes, and memory-like innate immunity. We resolve a small panel of plasma proteins that, when measured at diagnosis, can predict patient survival and recovery-trajectory commitment. Our study offers novel insights into post-acute immunological outcomes of COVID-19 that likely influence long-term adverse sequelae.

1 citations