L
Leila Youssefian
Researcher at Thomas Jefferson University
Publications - 108
Citations - 1390
Leila Youssefian is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Epidermolysis bullosa & Medicine. The author has an hindex of 17, co-authored 80 publications receiving 878 citations. Previous affiliations of Leila Youssefian include Tehran University of Medical Sciences & Thomas Jefferson University Hospital.
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Klippel-Trenaunay syndrome belongs to the PIK3CA-related overgrowth spectrum (PROS).
TL;DR: It appears that, rather than being a distinct diagnostic entity, KTS belongs to the PIK3CA‐related overgrowth spectrum (PROS), which has potential diagnostic and therapeutic implications for KTS.
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The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses.
Sarah Jill De Jong,Amandine Crequer,Irina Matos,David Hum,Vignesh Gunasekharan,Lazaro Lorenzo,Lazaro Lorenzo,Fabienne Jabot-Hanin,Fabienne Jabot-Hanin,E. Imahorn,Andrés Augusto Arias,Hassan Vahidnezhad,Hassan Vahidnezhad,Leila Youssefian,Leila Youssefian,Janet Markle,Etienne Patin,Aurelia D’Amico,Claire Q.F. Wang,Florian Full,Armin Ensser,Tina M. Leisner,Leslie V. Parise,Matthieu Bouaziz,Matthieu Bouaziz,Nataly Portilla Maya,Xavier Rueda Cadena,Bayaki Saka,Amir Hossein Saeidian,Nessa Aghazadeh,Sirous Zeinali,Peter Itin,James G. Krueger,Lou Laimins,Laurent Abel,Laurent Abel,Laurent Abel,Elaine Fuchs,Jouni Uitto,José Luis Franco,Bettina Burger,Gérard Orth,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Jean-Laurent Casanova +45 more
TL;DR: It is suggested that the disruption of CIB1-EVER1–EVER2-dependent keratinocyte-intrinsic immunity underlies the selective susceptibility to &bgr;-HPVs of EV patients.
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Applications of Spherical Nucleic Acid Nanoparticles as Delivery Systems
Ahad Mokhtarzadeh,Hassan Vahidnezhad,Leila Youssefian,Jafar Mosafer,Behzad Baradaran,Jouni Uitto +5 more
TL;DR: This work focuses on recent advances in the synthesis and application of SNAs in gene and drug delivery, diagnostics, and immunomodulation, as well as on the utility of nanoflares as intracellular mRNA detection systems.
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Molecular pathology of the basement membrane zone in heritable blistering diseases:: The paradigm of epidermolysis bullosa
TL;DR: EB serves as a paradigm of heritable skin diseases in which significant progress has been made in identifying the underlying genetic bases and associated aberrant pathways leading from mutations to the phenotype, thus allowing application of precision medicine for this, currently intractable group of diseases.
Journal ArticleDOI
Recessive mutation in tetraspanin CD151 causes Kindler syndrome-like epidermolysis bullosa with multi-systemic manifestations including nephropathy
Hassan Vahidnezhad,Leila Youssefian,Amir Hossein Saeidian,Hamidreza Mahmoudi,Andrew Touati,Maryam Abiri,Abdol-Mohammad Kajbafzadeh,Sophia Aristodemou,Lu Liu,John A. McGrath,Adam Ertel,Eric Londin,Ariana Kariminejad,Sirous Zeinali,Paolo Fortina,Jouni Uitto +15 more
TL;DR: A next-generation sequencing panel targeting genes known to be mutated in skin fragility disorders suggests that biallelic loss-of-function mutations in CD151 underlie an autosomal recessive mechano-bullous disease with systemic features.