L
Lena Allweiss
Researcher at University of Hamburg
Publications - 67
Citations - 5136
Lena Allweiss is an academic researcher from University of Hamburg. The author has contributed to research in topics: Hepatitis B virus & cccDNA. The author has an hindex of 24, co-authored 53 publications receiving 3559 citations. Previous affiliations of Lena Allweiss include American Board of Legal Medicine.
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Journal ArticleDOI
Multiorgan and Renal Tropism of SARS-CoV-2.
Victor G. Puelles,Marc Lütgehetmann,Maja T. Lindenmeyer,Jan Sperhake,Milagros N. Wong,Lena Allweiss,Silvia Chilla,Axel Heinemann,Nicola Wanner,Shuya Liu,Fabian Braun,Shun Lu,Susanne Pfefferle,Ann Sophie Schröder,Carolin Edler,Oliver Gross,Markus Glatzel,Dominic Wichmann,Thorsten Wiech,Stefan Kluge,Klaus Pueschel,Martin Aepfelbacher,Tobias B. Huber +22 more
TL;DR: In this autopsy series, the authors found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, heart, liver, and brai...
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Neuropathology of patients with COVID-19 in Germany: a post-mortem case series.
Jakob Matschke,Marc Lütgehetmann,Christian Hagel,Jan Sperhake,Ann Sophie Schröder,Carolin Edler,Herbert Mushumba,Antonia Fitzek,Lena Allweiss,Maura Dandri,Matthias Dottermusch,Axel Heinemann,Susanne Pfefferle,Marius Schwabenland,Daniel Sumner Magruder,Stefan Bonn,Stefan Bonn,Marco Prinz,Christian Gerloff,Klaus Püschel,Susanne Krasemann,Martin Aepfelbacher,Markus Glatzel +22 more
TL;DR: In general, neuropathological changes in patients with COVID-19 seem to be mild, with pronounced neuroinflammatory changes in the brainstem being the most common finding, and there was no evidence for CNS damage directly caused by SARS-CoV-2.
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IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
Laura Belloni,Lena Allweiss,Francesca Guerrieri,Natalia Pediconi,Tassilo Volz,Teresa Pollicino,Joerg Petersen,Giovanni Raimondo,Maura Dandri,Massimo Levrero +9 more
TL;DR: It is shown that IFN-α inhibits HBV replication by decreasing the transcription of pregenomic RNA and subgenomicRNA from the HBV covalently closed circular DNA minichromosome in cultured cells in which HBV is replicating and in mice whose livers have been repopulated with human hepatocytes and infected with HBV.
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The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus
Tassilo Volz,Lena Allweiss,Mounira Ben MBarek,Michael Warlich,Ansgar W. Lohse,J. M. Pollok,A. Alexandrov,Stephan Urban,Jörg Petersen,Marc Lütgehetmann,Maura Dandri +10 more
TL;DR: Myrcludex-B efficiently not only prevented HBV spreading from infected human hepatocytes in vivo, but also hindered amplification of the cccDNA pool in initially infected hepatocytes.
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Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation.
Marc Lütgehetmann,Lida V. Mancke,Tassilo Volz,Martina Helbig,Lena Allweiss,T. Bornscheuer,Joerg M. Pollok,Ansgar W. Lohse,Jörg Petersen,Stephan Urban,Maura Dandri +10 more
TL;DR: An efficient model of HBV/HDV infection is established to exploit mechanisms of viral interference in human hepatocytes and to test the efficacy of an HDV‐entry inhibitor in vivo.