V
Victor G. Puelles
Researcher at University of Hamburg
Publications - 88
Citations - 4242
Victor G. Puelles is an academic researcher from University of Hamburg. The author has contributed to research in topics: Medicine & Podocyte. The author has an hindex of 25, co-authored 67 publications receiving 2531 citations. Previous affiliations of Victor G. Puelles include Discovery Institute & Monash University.
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Journal ArticleDOI
Multiorgan and Renal Tropism of SARS-CoV-2.
Victor G. Puelles,Marc Lütgehetmann,Maja T. Lindenmeyer,Jan Sperhake,Milagros N. Wong,Lena Allweiss,Silvia Chilla,Axel Heinemann,Nicola Wanner,Shuya Liu,Fabian Braun,Shun Lu,Susanne Pfefferle,Ann Sophie Schröder,Carolin Edler,Oliver Gross,Markus Glatzel,Dominic Wichmann,Thorsten Wiech,Stefan Kluge,Klaus Pueschel,Martin Aepfelbacher,Tobias B. Huber +22 more
TL;DR: In this autopsy series, the authors found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, heart, liver, and brai...
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Decoding myofibroblast origins in human kidney fibrosis
Christoph Kuppe,Mahmoud M. Ibrahim,Mahmoud M. Ibrahim,Jennifer Kranz,Jennifer Kranz,Xiaoting Zhang,Susanne Ziegler,Javier Perales-Patón,Javier Perales-Patón,Jitske Jansen,Jitske Jansen,Jitske Jansen,Katharina C Reimer,James R Smith,Ross Dobie,John R. Wilson-Kanamori,Maurice Halder,Yaoxian Xu,Nazanin Kabgani,Nadine Kaesler,Martin Klaus,Lukas Gernhold,Victor G. Puelles,Victor G. Puelles,Tobias B. Huber,Peter Boor,Sylvia Menzel,Remco Hoogenboezem,Eric Bindels,Joachim Steffens,Jürgen Floege,Rebekka K. Schneider,Rebekka K. Schneider,Julio Saez-Rodriguez,Julio Saez-Rodriguez,Julio Saez-Rodriguez,Neil C. Henderson,Rafael Kramann,Rafael Kramann +38 more
TL;DR: Using single-cell RNA sequencing, the transcriptomes of cells from the proximal and non-proximal tubules of healthy and fibrotic human kidneys are profiled to map the entire human kidney and identify distinct subpopulations of pericytes and fibroblasts as the main cellular sources of scar-forming myofibro Blasts during human kidney fibrosis.
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SARS-CoV-2 renal tropism associates with acute kidney injury.
Fabian Braun,Marc Lütgehetmann,Susanne Pfefferle,Milagros N. Wong,Alexander Carsten,Maja T. Lindenmeyer,Dominik Nörz,Fabian Heinrich,Kira Meißner,Dominic Wichmann,Stefan Kluge,Oliver Gross,Klaus Pueschel,Ann Sophie Schröder,Carolin Edler,Martin Aepfelbacher,Victor G. Puelles,Tobias B. Huber +17 more
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Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target
Rebekka K. Schneider,Rebekka K. Schneider,Ann Mullally,Aurelien Dugourd,Fabian Peisker,Remco Hoogenboezem,Paulina M. H. van Strien,Eric M.J. Bindels,Dirk Heckl,Guntram Büsche,David Fleck,Gerhard Müller-Newen,Janewit Wongboonsin,Janewit Wongboonsin,Mónica S. Ventura Ferreira,Victor G. Puelles,Julio Saez-Rodriguez,Benjamin L. Ebert,Benjamin D. Humphreys,Rafael Kramann +19 more
TL;DR: It is shown that Gli1+ mesenchymal stromal cells are recruited from the endosteal and perivascular niche to become fibrosis-driving myofibroblasts in the bone marrow, and Gli1 expression in BMF significantly correlates with the severity of the disease.
Journal ArticleDOI
Cellular and Molecular Probing of Intact Human Organs
Shan Zhao,Mihail Ivilinov Todorov,Ruiyao Cai,Rami Ai Maskari,Hanno Steinke,Elisabeth Kemter,Hongcheng Mai,Zhouyi Rong,Martin Warmer,Karen Stanic,Oliver Schoppe,Johannes C. Paetzold,Benno Gesierich,Milagros N. Wong,Tobias B. Huber,Marco Duering,Oliver T. Bruns,Bjoern H. Menze,Jan Lipfert,Victor G. Puelles,Eckhard Wolf,Ingo Bechmann,Ali Ertürk +22 more
TL;DR: This work used SHANEL to render the intact adult human brain and kidney transparent and perform 3D histology with antibodies and dyes in centimeters-depth, and developed a deep learning pipeline to analyze millions of cells in cleared human brain tissues within hours with standard lab computers.