L
Leo J. de Koning
Researcher at University of Amsterdam
Publications - 72
Citations - 2256
Leo J. de Koning is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Ion cyclotron resonance & Spore. The author has an hindex of 28, co-authored 71 publications receiving 2075 citations. Previous affiliations of Leo J. de Koning include University of California, Berkeley & Martin Luther University of Halle-Wittenberg.
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Journal ArticleDOI
A structure for the yeast prohibitin complex: Structure prediction and evidence from chemical crosslinking and mass spectrometry.
Jaap Willem Back,Marta Artal Sanz,Luitzen de Jong,Leo J. de Koning,Leo G.J. Nijtmans,Chris G. de Koster,Les A. Grivell,Hans van der Spek,Anton O. Muijsers +8 more
TL;DR: A chaperone‐like function in holding and assembling newly synthesized mitochondrial polypeptide chains has been proposed, and a circular palisade‐like arrangement of the building blocks projecting into the intermembrane space is postulated.
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Mass‐specific selection of ions in Fourier‐transform ion cyclotron resonance mass spectrometry. Unintentional off‐resonance cyclotron excitation of selected ions
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Hyphal induction in the human fungal pathogen Candida albicans reveals a characteristic wall protein profile
Clemens J. Heilmann,Alice G. Sorgo,Adriaan R. Siliakus,Henk L. Dekker,Stanley Brul,Chris G. de Koster,Leo J. de Koning,Frans M. Klis +7 more
TL;DR: This is, to the authors' knowledge, the first systematic, quantitative analysis of the changes in the wall proteome of C. albicans upon hyphal induction and proposes new wall-protein-derived candidates for vaccine development.
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Selective Enrichment of Azide-Containing Peptides from Complex Mixtures
Merel A. Nessen,Gert Jan Kramer,JaapWillem Back,Jeremy M. Baskin,Linde E. J. Smeenk,Leo J. de Koning,Jan H. van Maarseveen,Luitzen de Jong,Carolyn R. Bertozzi,Henk Hiemstra,Chris G. de Koster +10 more
TL;DR: The enrichment method is found to be very specific, as after enrichment over 87% of all peptides contain (modified) azidohomoalanine.
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Surface stress induces a conserved cell wall stress response in the pathogenic fungus Candida albicans.
Clemens J. Heilmann,Alice G. Sorgo,Sepehr Mohammadi,Grazyna J. Sosinska,Chris G. de Koster,Stanley Brul,Leo J. de Koning,Frans M. Klis +7 more
TL;DR: It is proposed that surface stresses lead to a conserved cell wall remodeling response that is mainly governed by Mkc1 and is characterized by chitin reinforcement of the wall and the expression of remedial wall remodelling enzymes.