Clemens J. Heilmann

TL;DR: It is shown that growth on the physiologically relevant carboxylic acid, lactate, has a significant impact on the C. albicans cell wall proteome and secretome and this plasticity influences important fitness and virulence attributes known to modulate the behavior of C.Albicans in different host microenvironments during infection.

TL;DR: This is, to the authors' knowledge, the first systematic, quantitative analysis of the changes in the wall proteome of C. albicans upon hyphal induction and proposes new wall-protein-derived candidates for vaccine development.

TL;DR: It is proposed that surface stresses lead to a conserved cell wall remodeling response that is mainly governed by Mkc1 and is characterized by chitin reinforcement of the wall and the expression of remedial wall remodelling enzymes.

TL;DR: Fluconazole is a commonly used antifungal drug that inhibits Erg11, a protein responsible for 14α-demethylation during ergosterol synthesis, which causes increased membrane fluidity and drug permeability as discussed by the authors.

TL;DR: The number of identified secretory proteins in the growth medium has been substantially extended, and growth conditions strongly affect the composition of the secretome, indicating that C. albicans tightly regulates its secretome.