Leo McClusky

TL;DR: This study investigated TDP‐43 in a larger series of ALS cases, including familial cases with and without SOD1 mutations, and identified it as the major pathological protein in sporadic ALS.

TL;DR: The Deanna Protocol as mentioned in this paper includes nicotinamide adenine dinucleotide (NADH), coenzyme Q10 (CoQ10), and ubiquinol (a CoQ10 formulation), which are substances that also play a role in the citric acid cycle.

TL;DR: A subset of reviewers met in person and validated the utility of the TOE by attempting to convert the evidence from all 26 prior ALSUntangled reviews into this, using a ‘ crowd sourcing ’ approach.

TL;DR: There is little known about cannabinol, although it appears to have distinct pharmacological properties from cannabidiol, but it may provide some protection against seizures for epileptics.

TL;DR: Coconut oil could slow ALS progression simply by acting as a high calorie supplement that increases circulating lipids as mentioned in this paper, which could theoretically help compensate for mitochondrial dysfunction and impaired energy production in patients with ALS.