Leon D. Li

TL;DR: A high-throughput size-based separation method for processing diluted blood using inertial microfluidics is introduced, demonstrating the isolation of cancer cells spiked in blood by exploiting the difference in size between CTCs and hematologic cells.

TL;DR: The first direct measurements of detailed flow and electric potential profiles within and near the depletion region are reported, measuring and confirming that the electric field inside an ion depletion region is amplified more than 30-fold compared to outside of the depletion zone.

TL;DR: It is shown that certain configurations of positive and negative charges result in enhanced uptake into a mucin barrier, a remarkable effect that is not observed with either charge alone, and suggest that spatial charge distribution is a critical parameter to modulate transport through mucin-based barriers.

TL;DR: A simple microfluidic approach for intrinsic, non-specific removal of both microbes and inflammatory cellular components from whole blood, inspired by the invivo phenomenon of leukocyte margination is reported, which offers significant advantages including high throughput and label-free separation.

TL;DR: Using multiplexed, successive-concentration enhanced detection in the device, it is shown that the dynamic range and reliability of the immunoassay can be significantly increased.