L
Leonard D. Hudson
Researcher at University of Washington
Publications - 143
Citations - 19575
Leonard D. Hudson is an academic researcher from University of Washington. The author has contributed to research in topics: ARDS & Lung injury. The author has an hindex of 62, co-authored 143 publications receiving 18625 citations. Previous affiliations of Leonard D. Hudson include Harborview Medical Center & Emory University.
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Journal ArticleDOI
Incidence and Outcomes of Acute Lung Injury
Gordon D. Rubenfeld,Ellen Caldwell,Eve Peabody,Jim Weaver,Diane P. Martin,Margaret J. Neff,Eric J. Stern,Leonard D. Hudson +7 more
TL;DR: It is estimated that each year in the United States there are 190,600 cases of acute lung injury, which are associated with 74,500 deaths and 3.6 million hospital days, considerably higher than previous reports have suggested.
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Efficacy and Safety of Corticosteroids for Persistent Acute Respiratory Distress Syndrome
Kenneth P. Steinberg,Leonard D. Hudson,Richard B. Goodman,Catherine L. Hough,Paul N. Lanken,Robert C. Hyzy,B. Taylor Thompson,Marek Ancukiewicz +7 more
TL;DR: A multicenter, randomized controlled trial of corticosteroids in patients with persistent acute respiratory distress syndrome found that methylprednisolone improved survival and biochemical markers of inflammation and fibroproliferation, and infectious complications.
Journal ArticleDOI
Clinical predictors of the adult respiratory distress syndrome.
TL;DR: Of the ARDS cases, 76 percent occurred in the initial 24 hours after meeting the criteria, and ARDS did not occur after 72 hours unless there was late development of sepsis (3 of 136 patients).
Journal ArticleDOI
Cytokine balance in the lungs of patients with acute respiratory distress syndrome.
William Y. Park,Richard B. Goodman,Kenneth P. Steinberg,John T. Ruzinski,Frank Radella,David R. Park,Jérôme Pugin,Shawn J. Skerrett,Leonard D. Hudson,Thomas R. Martin +9 more
TL;DR: The molar ratios remained low for 7 d or longer, limiting the activity of soluble IL-1 beta and TNF-alpha in the lungs at the onset of ARDS.
Journal ArticleDOI
Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome.
Richard B. Goodman,Robert M. Strieter,Diane P. Martin,Kenneth P. Steinberg,John A. Milberg,Richard J. Maunder,Steven L. Kunkel,Alfred Walz,Leonard D. Hudson,Thomas R. Martin +9 more
TL;DR: IL-8 and ENA-78 were the cytokines most strongly and consistently correlated with PMN concentrations in the lung fluids of patients with ARDS, and the correlations were independent of the other cytokines or coexisting lung infection.