L
Leonard L. Jones
Researcher at University of California, San Diego
Publications - 31
Citations - 6522
Leonard L. Jones is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Microglia & Spinal cord injury. The author has an hindex of 27, co-authored 31 publications receiving 6260 citations. Previous affiliations of Leonard L. Jones include Veterans Health Administration & Max Planck Society.
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Journal ArticleDOI
Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function.
Gennadij Raivich,Marion Bohatschek,Christian U.A. Kloss,Alexander Werner,Leonard L. Jones,Georg W. Kreutzberg +5 more
TL;DR: Recent work in mice that are genetically deficient for different cytokines (MCSF, IL1, IL6, TNFalpha, TGFbeta1) has begun to shed light on the molecular signals that regulate this cellular response.
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Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury
TL;DR: Grafted NSCs were genetically modified to produce neurotrophin-3, which significantly expanded NSC effects on host axons and confirmed that grafted stem cells expressed neurotrophic factor genes in vivo.
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The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury.
TL;DR: Combined glial fibrillary acidic protein (GFAP) immunohistochemistry and in situ hybridization demonstrated that GFAP astrocytes constituted a source of neurocan production after spinal cord injury, establishing a CSPG-rich matrix that persists for up to 2 months following injury.
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NG2 Is a Major Chondroitin Sulfate Proteoglycan Produced after Spinal Cord Injury and Is Expressed by Macrophages and Oligodendrocyte Progenitors
TL;DR: Evaluation of total soluble CSPGs 2 weeks after dorsal column lesion in the rat demonstrated that NG2 is highly upregulated and is a major CSPG species, a major component of this putatively inhibitory class of ECM molecules expressed at sites of SCI and may restrict axonal regeneration.
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BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury
TL;DR: Bone marrow stromal cells can support host axonal growth after spinal cord injury and are suitable cell types for ex vivo gene delivery.